A molecular marker for diagnosing idiopathic inflammatory myopathy and its application

A molecular marker and idiopathic technology, applied in the field of medicine and biology, can solve the problems of time-consuming, inability to translate and modify proteins, etc.
CN110275026BActive Publication Date: 2022-04-22CHINA JAPAN FRIENDSHIP HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA JAPAN FRIENDSHIP HOSPITAL
Publication Date
2022-04-22

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Abstract

The invention relates to a molecular marker for diagnosing idiopathic inflammatory myopathy and its application. The molecular marker is autologous anti-heat shock transcription factor 1 (heat shock factor 1, HSF1) antibody in serum. The antibody is IgG; the idiopathic inflammatory myopathy is polymyositis (polymyositis, PM) or dermatomyositis (dermatomyositis, DM); the diagnosis is to distinguish idiopathic inflammatory myopathy and healthy population or to predict the disease process of idiopathic inflammatory myopathy (IIM).
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Description

technical field

[0001] The invention belongs to the technical field of medicine and biology, and specifically relates to a molecular marker for diagnosing idiopathic inflammatory myopathy and its application. Background technique

[0002] Idiopathic inflammatory myopathy (Idiopathic inflammatory myopathy, IIM) is a group of rare heterogeneous autoimmune diseases with proximal muscle weakness, abnormal serum muscle enzymes, inflammatory infiltration of skeletal muscle and extramuscular involvement as the main clinical manifestations. Including polymyositis (polymyositis, PM), dermatomyositis (dermatomyositis, DM) and inclusion body myositis (inclusion body myositis, IBM)[ 1 ]. Autoantibodies of IIM include myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs), which can be found in 60-80% of IIM patients. has significant value [ 2 , 3 ]. MSAs are associated with specific clinical syndromes and are only seen in IIM; whereas MAAs can be foun...

Claims

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