Specific gene markers for TMT (thyroid malignant tumor) and application of specific gene markers

Abstract

The invention relates to the field of medical detection, in particular to specific gene markers for TMT (thyroid malignant tumor) and an application of the specific gene markers. On the basis of a weighted gene coexpression network analysis method and by combination with clinical cases, the TMT is specifically correlated with abnormal expression of 17 gene markers and can be taken as a specific gene detection marker set. By means of verification of a large number of independent clinicopathological samples, specific mutation sites of 5 specific genes are further determined as molecular diagnosis markers. The related gene diagnosis marker set has important clinical application value for early molecular accurate diagnosis of the TMT, can be used for preparing a molecular diagnosis kit for detecting malignant thyroid nodules which are indeterminate according to clinical aspiration biopsy cytology, and particularly has important clinical application value for early molecular accurate diagnosis of patients with an uncertain FNAB (fine needle aspiration biopsy) cytology result of malignant thyroid nodules.

Description

technical field

[0001] The invention relates to the field of medical detection, in particular to specific gene markers of malignant thyroid tumors and applications thereof. Background technique

[0002] Thyroid cancer is one of the most common malignant tumors in the endocrine system, and its incidence is rapidly increasing worldwide. It is very important to establish an accurate early diagnosis method to intervene in the process of thyroid tumors to malignant tumors. At present, fine-needle aspiration biopsy is the most accurate and economical method in the clinical evaluation of thyroid nodules, and is recommended by the American Thyroid Association as a standardized clinical practice. However, in approximately 30% of clinical cases in fine-needle aspiration biopsies, cytology results are significantly inconclusive, and the tested specimens are flagged as indeterminate or suspected malignancy requiring partial or complete thyroidectomy and further follow-up. Histological...

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