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Compound oxyclozanide suspension composition and preparation method and application thereof

A technology of penclosamide and its composition, which is applied in the field of compound penclosamide suspension composition and its preparation, can solve the problems of singleness, insignificant insect repelling effect, narrow insect resistance spectrum, etc., and achieve increased mucus volume, Effect of improving feed remuneration and enhancing stability

Pending Publication Date: 2019-10-08
四川恒通动保生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the anthelmintic drugs currently on the market generally have problems such as narrow anti-insect spectrum, insignificant and single anthelmintic effect

Method used

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  • Compound oxyclozanide suspension composition and preparation method and application thereof
  • Compound oxyclozanide suspension composition and preparation method and application thereof
  • Compound oxyclozanide suspension composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Accurately weigh 3kg of bentonite, add it into 10L of water while stirring, and soak for more than 4h, wait for natural swelling, and stir evenly;

[0026] (2) Accurately weigh 500g of syrup, heat it with 5L of water until completely dissolved, and set aside;

[0027] (3) Take 10kg of propylene glycol to the liquid mixing container, add 6kg of pentaclosamide, 300g of polyethylene glycol lauryl hydroxystearate, 100g of propylparaben and 100g of sodium lauryl sulfate, and stir well , add the pre-soaked bentonite solution and syrup solution, and stir evenly;

[0028] (4) Add 3kg of levamisole hydrochloride, 400g of cobalt sulfate, 300g of edetate disodium and 300g of sodium citrate, add water and set the volume to 100L, stir evenly, and pass through a homogenizer while stirring;

[0029] (5) The pH value is adjusted to 4.5-5.5 with citric acid and sodium citrate to obtain fine-grained veterinary compound penclosamide oral suspension.

Embodiment 2

[0031] (1) Accurately weigh 3kg of bentonite, add it into 10L of water while stirring, and soak for more than 4h, wait for natural swelling, and stir evenly;

[0032] (2) Accurately weigh 500g of syrup, heat it with 5L of water until completely dissolved, and set aside;

[0033] (3) Take 10kg of propylene glycol to the liquid mixing container, add 5kg of pentaclosamide, 300g of polyethylene glycol lauryl hydroxystearate, 100g of propylparaben and 100g of sodium lauryl sulfate, and stir well , add the pre-soaked bentonite solution and syrup solution, and stir evenly;

[0034] (4) Add 3.5kg of levamisole hydrochloride, 500g of cobalt sulfate, 300g of edetate disodium and 300g of sodium citrate, add water to 100L, stir evenly, and pass through a homogenizer while stirring;

[0035] (5) The pH value is adjusted to 4.5-5.5 with citric acid and sodium citrate to obtain the compound penclosamide oral suspension liquid for veterinary use with fine particles.

Embodiment 3

[0037] (1) Accurately weigh 4kg of bentonite, add in 10L of water while stirring, and soak for more than 4h, wait for natural swelling, and stir evenly;

[0038] (2) Accurately weigh 500g of syrup, heat it with 5L of water until completely dissolved, and set aside;

[0039] (3) Take 12kg of propylene glycol to the liquid mixing container, add 7kg of pentaclosamide, 200g of polyethylene glycol lauryl hydroxystearate, 100g of propylparaben and 100g of sodium lauryl sulfate, and stir evenly , add the pre-soaked bentonite solution and syrup solution, and stir evenly;

[0040] (4) Add 4kg of levamisole hydrochloride, 450g of cobalt sulfate, 300g of edetate disodium and 300g of sodium citrate, add water and set the volume to 100L, stir evenly, and pass through a homogenizer while stirring;

[0041] (5) The pH value is adjusted to 4.5-5.5 with citric acid and sodium citrate to obtain fine-grained veterinary compound penclosamide oral suspension.

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Abstract

The invention discloses a compound oxyclozanide suspension composition and a preparation method and application thereof. Each 100ml of the composition comprises, by weight, 1-10 parts of oxyclozanide,1-5 parts of levamisole hydrochloride and 0.1-2 parts of cobalt sulfate. The composition is used for preventing and treating mixed infection and parasitic diarrhea caused by nematodes, trematodes andthe like.

Description

technical field [0001] The invention relates to the field of animal medicine, in particular to a compound penclosamide suspension composition and a preparation method and application thereof. Background technique [0002] The prevalence of parasitic diseases not only hinders the development of animal husbandry, endangers human health, but also causes serious economic losses to animal husbandry. Animals such as cattle and sheep have many parasites, and most of them are mixed infections such as nematodes and trematodes. In addition, parasitic infections in cattle and sheep can easily cause secondary infections such as parasitic diarrhea. [0003] However, the anthelmintic drugs currently on the market generally have problems such as narrow anti-insect spectrum, insignificant and single anthelmintic effect. Contents of the invention [0004] One of the objects of the present invention is to provide a compound penclosamide suspension composition made of penclosamide, levamiso...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K47/02A61K47/14A61K33/24A61K31/167A61K31/429A61P33/00
CPCA61K9/10A61K31/167A61K31/429A61K33/24A61K47/02A61K47/14A61P33/00A61K2300/00
Inventor 胡军刘起军吴成剑郭亮
Owner 四川恒通动保生物科技有限公司
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