Membrane agent capable of being quickly dissolved in oral cavity and preparation method of membrane agent

A fast and oral technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as the lack of research on semaglutide, and achieve the convenience of industrialized mass production, Small size, rapid drug release effect

Active Publication Date: 2019-10-22
CHENGDU SINTANOVO BIOTECHNOLOGV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006]Currently, semaglutide should mainly include injection and oral administration, and there is no research on semaglutide in oral film

Method used

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  • Membrane agent capable of being quickly dissolved in oral cavity and preparation method of membrane agent
  • Membrane agent capable of being quickly dissolved in oral cavity and preparation method of membrane agent
  • Membrane agent capable of being quickly dissolved in oral cavity and preparation method of membrane agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A film that dissolves quickly in the oral cavity and consists of the following parts by weight:

[0053] Semaglutide 0.128g, hydroxymethylpropyl cellulose 1g, 1,2-propanediol 0.15g, and the viscosity of the hydroxymethylpropyl cellulose is 15 cP.

Embodiment 2

[0055] A film that dissolves quickly in the oral cavity and consists of the following parts by weight:

[0056] Semaglutide is 0.128 g, maltodextrin is 1 g, 1,2-propanediol is 0.15 g, and the viscosity of the hydroxymethyl propyl cellulose is 15 cP.

Embodiment 3

[0058] A film that dissolves quickly in the oral cavity and consists of the following parts by weight:

[0059] Semaglutide 0.155g, maltodextrin 0.4g, hydroxymethylpropyl cellulose 0.6g, glycerol 0.3g, pregelatinized starch 0.1g, the viscosity of the hydroxymethylpropyl cellulose is 15cP.

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Abstract

The invention discloses a membrane agent capable of being quickly dissolved in the oral cavity and a preparation method of the membrane agent. The membrane agent is prepared from, by weight, 0.09-0.155 part of a medicine active component, 0.6-1 part of a water-soluble membrane formation material, 0.15-0.3 part of a plasticizer and 0-0.1 part of a disintegrant. Compared with an injection agent andan oral agent, the membrane agent has the advantages that the membrane agent can avoid the digestive system and is quickly dissolved and absorbed in the oral cavity. The preparation method of the membrane agent is simple, economical and practical, and convenience is provided for industrialization batch production.

Description

Technical field [0001] The invention relates to the technical field of oral membranes, in particular to a membrane that dissolves quickly in the oral cavity and a preparation method thereof. Background technique [0002] With the aging of the population, urbanization and changing lifestyles, the number of diabetes patients worldwide has more than doubled in the past three decades. Diabetes (diabetes mellitus, DM) is caused by the long-term interaction of genetic factors and environmental factors caused by insufficient insulin secretion or defective function, and accompanied by a dual hormone disease in which glucagon is not suitable to increase. The increase in blood glucose level is Biochemical characteristics and metabolic disorder syndrome with clinical features such as polydipsia, polyphagia, polyuria, weight loss, and fatigue. Diabetes is a common metabolic disorder in which blood sugar (glucose) rises and then flows away from the urine, so there is sugar in the urine. Spe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/10A61K47/38A61K47/36A61K38/26A61P3/10
CPCA61K9/006A61K47/10A61K47/38A61K47/36A61K38/26A61P3/10Y02A50/30
Inventor 于双高剑李元波戴媚易小军陈廷廷卢玉容刘彩玲
Owner CHENGDU SINTANOVO BIOTECHNOLOGV CO LTD
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