3,4-dihydrogen-benzo[f][1,4] thiazepine*-5(2H)-ketones and their applications in medicine
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- FUDAN UNIV
- Publication Date
- 2019-11-05
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of medicine, and relates to a new class of 3,4-dihydro-benzo[f][1,4]thiazepines with the structure of formula I -5(2H)-ketone compounds and their medicinal uses. Formula I structure 3,4-dihydro-benzo[f][1,4]thiazepine described in the present invention -5(2H)-ketone compounds are non-ATP competitive inhibitors of glycogen synthesis kinase-3β (GSK-3β), which can inhibit the activity of GSK-3β at micromolar concentrations, and have no inhibitory effect on various protein kinases tested. No obvious inhibitory effect. The compound of the formula I has good in vitro inhibitory activity on cancers, such as ovarian cancer, and can be used to treat cancers such as ovarian cancer. The compound of formula I described in the present invention can be used to prepare medicines for preventing and / or treating diseases with abnormal pathological characteristics of GSK 3β, such diseases include cancer, neurological diseas...