A kind of nanocomposite material, its preparation method and the application in hifu synergist

Abstract

The application discloses a nanocomposite material, which is characterized in that it includes an inner core component and an outer layer component; the inner core component includes nanoparticles; the outer layer component is a multilayer component, including a stabilizer, a medical At least one of imaging contrast agent, chemotherapy drug, tumor-specific ligand or antibody; the mass ratio of the inner core component to the outer layer component is 1:10˜1:0.5. The nanocomposite material has ultrasonic response activity, and can efficiently convert absorbed ultrasonic waves into active oxygen radicals or heat energy. This application also discloses its preparation method and its application in HIFU synergists. The preparation method is simple and easy, which is conducive to large-scale production and promotion; when it is used in HIFU synergists, it can improve the effect of HIFU on deep lesions. The ablation effect can improve the therapeutic effect on small early tumors, and can perform imaging positioning and identification of tumor borders, reducing damage to normal tissues at tumor borders.

Description

technical field [0001] The present application relates to a nanocomposite material, a preparation method thereof and an application in a HIFU synergist, belonging to the fields of nanomaterials and HIFU. Background technique [0002] High intensity focused ultrasound (HIFU) is a non-invasive local tumor ablation technique. It focuses the high-energy ultrasound to the lesion tissue, and realizes the coagulation necrosis of the lesion tissue through the instantaneous high temperature effect and cavitation effect generated by the ultrasound. At present, HIFU has been used in the clinical treatment of various tumors, and has shown good therapeutic effects and application prospects in liver cancer, cervical cancer, uterine fibroids, and prostate tumors. [0003] However, in the process of clinical promotion of HIFU technology, several key problems that hinder its further promotion need to be solved. First, in the process of HIFU treatment, the ultrasonic energy shows the charac...

AI Technical Summary

Problems solved by technology

[0003] However, in the process of clinical promotion of HIFU technology, several key problems hindering its further promotion have been encountered and need to be solved

First, in the process of HIFU treatment, the ultrasonic energy shows the characteristics of rapid attenuation due to tissue absorption during the propagation process in the body. Therefore, for deep lesions, the ablation effect of HIFU will be reduced.

Although it is clinically possible to counteract the influence of tissue absorption by increasing the ultrasonic output power and enhance the ablation effect of HIFU on the lesion tissue, excessive output power will cause tissue damage on the ultrasonic propagation path. Therefore, increasing the output power cannot effectively solve the problem. Thorough ablation of deep lesions by HIFU

Second, HIFU is a non-invasive tumor ablation technology based on imaging. Therefore, effective detection of tumors, especially small early tumors, by imaging equipment such as MRI is a prerequisite for effective HIFU treatment. Tumor-specific imaging contrast agents for HIFU technology

Third, HIFU cannot accurately identify tumor tissue boundaries during the treatment of solid tumors, which will lead to tumor recurrence and metastasis caused by damage to normal tissues around the tumor during treatment and inability to completely ablate tumor boundaries

Images