Tea tree oil microspheres with bacteriostatic effect and preparation method thereof

A technology of antibacterial effect and tea tree oil, which is applied in the field of tea tree oil microspheres and its preparation, can solve the problems of high price and achieve the effects of convenient operation, good moisturizing effect and simple process

Inactive Publication Date: 2019-11-22
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, 2 million patients received treatment caused by burns, and most patients received new skin tissue through autologous or allogeneic transplantation, which is expensive and will induce more severe immune rejection

Method used

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  • Tea tree oil microspheres with bacteriostatic effect and preparation method thereof
  • Tea tree oil microspheres with bacteriostatic effect and preparation method thereof
  • Tea tree oil microspheres with bacteriostatic effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method of tea tree oil microspheres with bacteriostasis, comprising the following steps:

[0031] (1) Dissolve 1g silk fibroin in deionized water to make the concentration 1% (w / v);

[0032] (2) Dissolve 1g of hyaluronic acid in deionized water to a concentration of 1% (w / v);

[0033] (3) Mix the silk fibroin solution prepared in step (1) and the hyaluronic acid solution prepared in step (2) at a volume ratio of 1:1 to form a 250ul organic phase intercalator, and stir magnetically for 30min to make it well mixed;

[0034] (4) Add 5mL tea tree oil to the mixed solution obtained in step (3), and stir it magnetically for 2 hours, so that the organic inner phase is evenly distributed in the tea tree oil, and obtain a water-in-oil type tea tree oil primary emulsion, which is prepared under ultrasonic conditions. Slowly add 0.025g Tween 80 dropwise into the tea tree oil primary emulsion, ultrasonicate for 10 minutes with a homogenizer, and process with a vorte...

Embodiment 2

[0038] A preparation method of tea tree oil microspheres with bacteriostasis, comprising the following steps:

[0039] (1) Dissolve 1.5g silk fibroin in deionized water to make the concentration 1.5% (w / v);

[0040] (2) Dissolve 1.5g of hyaluronic acid in deionized water to a concentration of 1.5% (w / v);

[0041] (3) Mix the silk fibroin protein prepared in step (1) and the hyaluronic acid solution prepared in step (2) at a volume ratio of 1:1 to form a 250ul organic phase intercalator, and stir magnetically for 30 minutes to mix uniform;

[0042](4) Add 5 mL of tea tree oil to the mixed liquid obtained in step (3), and stir magnetically for 2 hours, so that the organic inner phase is evenly distributed in the tea tree oil, and a water-in-oil type tea tree oil primary emulsion is obtained, and the Slowly add 0.05 g of Tween 80 dropwise to the obtained tea tree oil primary emulsion, ultrasonicate the homogenizer for 10 minutes, and process with a vortex machine for 15 minutes...

Embodiment 3

[0046] A preparation method of tea tree oil microspheres with bacteriostasis, comprising the following steps:

[0047] (1) Dissolve 2g silk fibroin in deionized water to make the volume concentration 2% (w / v);

[0048] (2) Dissolve 2g of hyaluronic acid in deionized water to a volume concentration of 2% (w / v)

[0049] (3) Mix the silk fibroin protein prepared in step (1) and the hyaluronic acid solution prepared in step (2) at a volume ratio of 1:1 to form a 500ul organic phase intercalator, and stir magnetically for 30 minutes to mix Uniform;

[0050] (4) Add 5 mL of tea tree oil to the mixed liquid obtained in step (3), and stir magnetically for 2 hours, so that the organic inner phase is evenly distributed in the tea tree oil, and a water-in-oil type tea tree oil primary emulsion is obtained, and the Slowly add 0.05 g of Tween 80 dropwise to the obtained tea tree oil primary emulsion, ultrasonicate the homogenizer for 10 minutes, and process with a vortex machine for 15 m...

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Abstract

The invention discloses tea tree oil microspheres with a bacteriostatic effect and a preparation method thereof. A biological mechanism and an ultrasonic emulsification preparation technology are adopted, tea tree oil is selected as an oil phase, an organic phase of silk fibroin and hyaluronic acid serves as an embedded body, Tween 80 serves as an emulsion, and the two phases are mixed to preparethe microspheres with the bacteriostatic effect. The selected materials have good biocompatibility and a good moisturizing effect, slow release and interface phase separation are achieved by using a natural product delivery system, the skin respiration is not influenced while the external environment fluid is resisted to prevent inflammatory infections, and the skin regeneration is induced; a layer-by-layer self-assembled stable oil phase and water phase interface is achieved by uniformly dispersing tea tree oil particles of the oil phase on an organic matrix; through the selection and combination of the organic particles and tea tree oil, the tea tree essential oil microspheres with the bacteriostatic effect are bionically prepared.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a tea tree oil microsphere with antibacterial effect and a preparation method thereof. Background technique [0002] Burns are one of the most common and devastating forms of trauma. Infection and repair of burn wounds are mainly associated with changes in the activity of Gram-positive and Gram-negative bacteria. In the early stages of burn injury, the wound site is a sensitive site for opportunistic colonization by endogenous and exogenous organisms. Patient factors such as age, extent of injury, and depth of burn affect the likelihood and intensity of traumatic burn infection. According to statistics, about 40,000 fires are reported in China every year, causing 26 million burns. Moderate and severe burn patients requiring hospitalization accounted for about 10 million cases, and about 2,300 patients died of burn-related complications, with an average lo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61K9/52A61K47/42A61K47/36A61P31/02A61P17/02A61P31/04
CPCA61K9/0014A61K9/5036A61K9/5052A61K36/61A61P17/02A61P31/02A61P31/04
Inventor 陈景帝邹琳耿玉生徐敢陈立
Owner FUZHOU UNIV
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