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A natural medicine preparation for preventing and treating atherosclerosis by regulating the balance of intestinal flora

A technology for atherosclerosis and regulation of intestinal flora, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve chronic problems, inappropriate resistance, etc., and save time , high extraction rate and transfer rate, remarkable effect

Active Publication Date: 2022-02-15
JIYANG COLLEGE OF ZHEJIANG A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While acute inflammation is beneficial, chronic inflammation can become problematic and inappropriately against the body's own tissues

Method used

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  • A natural medicine preparation for preventing and treating atherosclerosis by regulating the balance of intestinal flora
  • A natural medicine preparation for preventing and treating atherosclerosis by regulating the balance of intestinal flora
  • A natural medicine preparation for preventing and treating atherosclerosis by regulating the balance of intestinal flora

Examples

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Effect test

Embodiment 1

[0046]1. The preparation method of the described black corncob anthocyanin extraction and purification is as follows: the low-temperature air-dried black corncob is placed in a tissue crushing extractor, and the solid-liquid ratio is added to 50% ethanol at pH 3.0 of 1:6 The solution was crushed and extracted at room temperature for 2 min. Suction filtration, the resulting filter residue was added to a 50% ethanol solution with a solid-to-liquid ratio of 1:5 and pH 3.0, and ultrasonic extraction was used instead of ultrasonic extraction at room temperature for 1 time, extraction for 40 minutes, and suction filtration. The tissue fragmentation extract and the ultrasonic extract were combined, and concentrated by flash evaporation at 40°C to 1 / 6 of the original volume to obtain a concentrate. The concentrated solution was enriched and purified by macroporous adsorption resin Diaion HP 2MGL column chromatography for total anthocyanins. Rinse with distilled water until the eluent...

Embodiment 2

[0051] 1. The preparation method of the described black corncob anthocyanin extraction and purification is as follows: the low-temperature air-dried black corncob is placed in a tissue crushing extractor, and the solid-liquid ratio is 1:4 by adding 55% ethanol of pH 3.0 The solution was crushed and extracted at room temperature for 2 min. Suction filtration, the resulting filter residue was added to a 55% ethanol solution with a solid-to-liquid ratio of 1:3 and pH 3.0, and ultrasonic extraction was used instead of ultrasonic extraction at room temperature for 1 time, extraction for 30 minutes, and suction filtration. The tissue crushing extract and the ultrasonic extract were combined, flash-concentrated at 45°C to 1 / 5 of the original volume to obtain a concentrate. The concentrated solution was enriched and purified by macroporous adsorption resin Diaion HP 2MGL column chromatography for total anthocyanins. Rinse with distilled water until the eluate is colorless and transpa...

Embodiment 3

[0056] 1. The preparation method of the described black corncob anthocyanin extraction and purification is as follows: the low-temperature air-dried black corncob is placed in a tissue crushing extractor, and the solid-liquid ratio is 1:5 by adding 50% ethanol with a pH of 3.0 The solution was crushed and extracted at room temperature for 2 min. Suction filtration, the resulting filter residue was added to a 55% ethanol solution with a solid-to-liquid ratio of 1:4 and pH 3.0, and ultrasonic extraction was used instead of ultrasonic extraction at room temperature for 1 time, extracted for 35 minutes, and suction filtered. The tissue crushing extract and the ultrasonic extract were combined, flash-concentrated at 50°C to 1 / 5 of the original volume to obtain a concentrate. The concentrated solution was enriched and purified by macroporous adsorption resin Diaion HP 2MGL column chromatography for total anthocyanins. Rinse with distilled water until the eluate is colorless and tra...

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Abstract

The invention relates to a natural medicine preparation for preventing and treating atherosclerosis by regulating the balance of intestinal flora, belonging to the technical field of traditional Chinese medicine research. It consists of the following components in percentage by weight: 40%-50% of the purified anthocyanin extract of black corncobs, 10%-25% of the purified extract of total flavonoids of Mimosa, 20%-30% of the purified extract of tannins from loropetalum mosaic, Curcumin 10%‑20%. The above-mentioned technical solution of a natural medicine preparation for preventing and treating atherosclerosis by regulating the balance of intestinal flora has a reasonable formula, is environmentally friendly, has good safety, and is suitable for long-term use. Through the synergistic enhancement of each component, it has obvious therapeutic effect on rats with atherosclerosis. The special composition makes the product have remarkable efficacy in treating atherosclerosis and is convenient to take. At the same time, the main raw material black corncob used in the present invention is plant waste, and the source of raw material is abundant, turning waste into treasure, and improving the reutilization rate of resources.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine research, in particular to a natural medicine preparation for preventing and treating atherosclerosis by regulating the balance of intestinal flora. Background technique [0002] Atherosclerosis is the pathological basis of cardiovascular and cerebrovascular diseases. According to surveys, the mortality rate of cardiovascular and cerebrovascular diseases in my country has surpassed that of tumors, becoming the number one killer of health hazards. With the continuous improvement of people's living standards, high-fat, high-sugar, high-calorie diets cause a series of metabolic diseases, such as hypertension, hyperlipidemia, diabetes, obesity, fatty liver, cardiovascular and cerebrovascular diseases, etc. According to the survey, metabolic diseases The morbidity and mortality of vascular diseases caused by diseases, especially hyperlipidemia, are increasing year by year, and the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61K36/48A61P9/10A61K31/353A61K31/12
CPCA61K36/899A61K31/353A61K36/48A61K36/185A61K31/12A61P9/10A61K2236/333A61K2236/39A61K2236/55A61K2236/33A61K2300/00
Inventor 金松恒袁珂罗阳方继利
Owner JIYANG COLLEGE OF ZHEJIANG A & F UNIV
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