Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A natural hypoglycemic preparation that exerts hypoglycemic effect by regulating the balance of intestinal flora

A technology for regulating intestinal flora and hypoglycemic, applied in medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, pharmaceutical formulations, etc., to achieve the effects of good quality, high retention rate, and high extraction rate

Active Publication Date: 2021-11-16
杭州御寿生物科技有限公司
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that the two flavonoids in Fructus officinalis are 4',5-dihydroxy-3,3',7,8-tetramethoxyflavone and 3,5-dimethoxy-6,7;3 Anti-DNA and RNA virus experiments done by ',4'-bismethylenedioxyflavone (selected viruses include poliovirus, adenovirus, herpes virus HSVI and type II, VSV virus) show that: these two Flavonoids Under the same experimental conditions, 4',5-dihydroxy-3,3',7,8-tetramethoxyflavone has inhibitory effect on the cytopathic effect caused by the experimental virus, but 3,5-dimethyl Oxy-6,7; 3',4'-bismethylenedioxyflavone does not

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A natural hypoglycemic preparation that exerts hypoglycemic effect by regulating the balance of intestinal flora
  • A natural hypoglycemic preparation that exerts hypoglycemic effect by regulating the balance of intestinal flora
  • A natural hypoglycemic preparation that exerts hypoglycemic effect by regulating the balance of intestinal flora

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. The preparation method of the described rhubarb total anthraquinone glycosides extraction and purification is as follows: take the dried and pulverized rhubarb coarse powder, and use 65% ethanol with a solid-liquid ratio of 1:5 to do solvent reflux extraction for 2 times, each time for 20 minutes . Suction filtration, combined extracts, vacuum flash concentration at 60°C to 1 / 8 of the original volume. The extract concentrate was extracted with petroleum ether, ethyl acetate and n-butanol, respectively, and concentrated by vacuum flash evaporation and rotary evaporation at 60°C to dryness to obtain various fractions. The n-butanol extraction part was enriched and purified by Diaion HP-20 macroporous adsorption resin column chromatography, and gradient washing was carried out with deionized water, 10% ethanol, 20% ethanol, 40% ethanol, 60% ethanol, and 70% acetone respectively. take off. The 40% ethanol and 60% ethanol fractions were combined, flashed and concentrate...

Embodiment 2

[0050] 1. The preparation method of the described rhubarb total anthraquinone glycosides extraction and purification is as follows: take the dried and pulverized rhubarb coarse powder, and use 75% ethanol with a solid-liquid ratio of 1:8 to do solvent reflux extraction for 3 times, each time for 40 minutes . Suction filtration, combined extracts, and vacuum flash concentration at 50°C to 1 / 12 of the original volume. The extract concentrate was extracted with petroleum ether, ethyl acetate and n-butanol, respectively, and concentrated by vacuum flash evaporation at 50°C combined with rotary evaporation to dryness to obtain various fractions. The n-butanol extraction part was enriched and purified by Diaion HP-20 macroporous adsorption resin column chromatography, and gradient washing was carried out with deionized water, 10% ethanol, 20% ethanol, 40% ethanol, 60% ethanol, and 70% acetone respectively. take off. The 40% ethanol and 60% ethanol fractions were combined, flashed ...

Embodiment 3

[0056] 1. The preparation method of the described rhubarb total anthraquinone glycosides extraction and purification is as follows: take the dried and pulverized rhubarb coarse powder, and use 75%% ethanol with a solid-liquid ratio of 1:6 to do solvent reflux extraction for 2 times, each time 30 minute. Suction filtration, combined extracts, and vacuum flash concentration at 55°C to 1 / 10 of the original volume. The extract concentrate was extracted with petroleum ether, ethyl acetate and n-butanol, respectively, and concentrated by vacuum flash evaporation at 55°C combined with rotary evaporation to dryness to obtain various fractions. The n-butanol extraction part was enriched and purified by Diaion HP-20 macroporous adsorption resin column chromatography, and gradient washing was carried out with deionized water, 10% ethanol, 20% ethanol, 40% ethanol, 60% ethanol, and 70% acetone respectively. take off. The 40% ethanol and 60% ethanol fractions were combined, flashed and c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a natural hypoglycemic preparation exerting a hypoglycemic effect by regulating the balance of intestinal flora, belonging to the technical field of traditional Chinese medicine research. It consists of the following substances in percentage by weight: 30%-50% of rhubarb total anthraquinone glycosides extraction and purification, 10%-20% of honey cornel total flavonoids extraction and purification, 15%-25% of ghostly polyphenols extraction and purification, Ginger Gardenia Extract 20%‑30%. The above-mentioned natural hypoglycemic preparation exerts a hypoglycemic effect by regulating the balance of intestinal flora. Its product formula is reasonable, green, environmentally friendly, safe, and suitable for long-term use; It has a very good effect on protecting the intestinal flora and treating type II diabetes; this special composition makes the product effective in reducing blood sugar and fat, and is convenient to take.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine research, and specifically relates to a natural hypoglycemic preparation that exerts hypoglycemic effect by regulating the balance of intestinal flora. Background technique [0002] Diabetes mellitus (Diabetes Mellitus) is a chronic metabolic disease characterized by chronic hyperglycemia caused by insulin deficiency. Diabetes can cause many complications and seriously affect the quality of life and longevity of patients. Due to the complexity of the etiology, modern medical methods cannot completely overcome it, and it is still a lifelong disease. In the current clinical treatment of diabetes in China, traditional medical methods, especially the use of natural products, have played an important role in the treatment of diabetes. In recent years, with the development of social economy and the transformation of lifestyle, the incidence of diabetes has increased significantly, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61P1/00A61P3/10
Inventor 袁珂方继莉罗阳
Owner 杭州御寿生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com