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Natural hypoglycemic agent capable of exerting hypoglycemic effects by regulating balance of intestinal flora

A technology for regulating intestinal flora and lowering blood sugar, which is applied to medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, plant raw materials, etc., to achieve high extraction rate, good quality, and hypoglycemic and lipid-lowering effects significant effect

Active Publication Date: 2019-06-14
杭州御寿生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that the two flavonoids in Fructus officinalis are 4',5-dihydroxy-3,3',7,8-tetramethoxyflavone and 3,5-dimethoxy-6,7;3 Anti-DNA and RNA virus experiments done by ',4'-bismethylenedioxyflavone (selected viruses include poliovirus, adenovirus, herpes virus HSVI and type II, VSV virus) show that: these two Flavonoids Under the same experimental conditions, 4',5-dihydroxy-3,3',7,8-tetramethoxyflavone has inhibitory effect on the cytopathic effect caused by the experimental virus, but 3,5-dimethyl Oxy-6,7; 3',4'-bismethylenedioxyflavone does not

Method used

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  • Natural hypoglycemic agent capable of exerting hypoglycemic effects by regulating balance of intestinal flora
  • Natural hypoglycemic agent capable of exerting hypoglycemic effects by regulating balance of intestinal flora
  • Natural hypoglycemic agent capable of exerting hypoglycemic effects by regulating balance of intestinal flora

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Effect test

Embodiment 1

[0044] 1. The preparation method of the described rhubarb total anthraquinone glycosides extraction and purification is as follows: take the dried and pulverized rhubarb coarse powder, and use 65% ethanol with a solid-liquid ratio of 1:5 to do solvent reflux extraction for 2 times, each time for 20 minutes . Suction filtration, combined extracts, vacuum flash concentration at 60°C to 1 / 8 of the original volume. The extract concentrate was extracted with petroleum ether, ethyl acetate and n-butanol, respectively, and concentrated by vacuum flash evaporation at 60°C combined with rotary evaporation to dryness to obtain various fractions. The n-butanol extraction part was enriched and purified by Diaion HP-20 macroporous adsorption resin column chromatography, and gradient washing was carried out with deionized water, 10% ethanol, 20% ethanol, 40% ethanol, 60% ethanol, and 70% acetone respectively. take off. The 40% ethanol and 60% ethanol fractions were combined, flashed and c...

Embodiment 2

[0050] 1. The preparation method of the described rhubarb total anthraquinone glycosides extraction and purification is as follows: take the dried and pulverized rhubarb coarse powder, and use 75% ethanol with a solid-liquid ratio of 1:8 to do solvent reflux extraction for 3 times, each time for 40 minutes . Suction filtration, combined extracts, and vacuum flash concentration at 50°C to 1 / 12 of the original volume. The extract concentrate was extracted with petroleum ether, ethyl acetate and n-butanol, respectively, and concentrated by vacuum flash evaporation at 50°C combined with rotary evaporation to dryness to obtain various fractions. The n-butanol extraction part was enriched and purified by Diaion HP-20 macroporous adsorption resin column chromatography, and gradient washing was carried out with deionized water, 10% ethanol, 20% ethanol, 40% ethanol, 60% ethanol, and 70% acetone respectively. take off. The 40% ethanol and 60% ethanol fractions were combined, flashed ...

Embodiment 3

[0056] 1. The preparation method of the described rhubarb total anthraquinone glycosides extraction and purification is as follows: take the dried and pulverized rhubarb coarse powder, and use 75%% ethanol with a solid-liquid ratio of 1:6 to do solvent reflux extraction for 2 times, each time 30 minute. Suction filtration, combined extracts, and vacuum flash concentration at 55°C to 1 / 10 of the original volume. The extract concentrate was extracted with petroleum ether, ethyl acetate and n-butanol, respectively, and concentrated by vacuum flash evaporation at 55°C combined with rotary evaporation to dryness to obtain various fractions. The n-butanol extraction part was enriched and purified by Diaion HP-20 macroporous adsorption resin column chromatography, and gradient washing was carried out with deionized water, 10% ethanol, 20% ethanol, 40% ethanol, 60% ethanol, and 70% acetone respectively. take off. The 40% ethanol and 60% ethanol fractions were combined, flashed and c...

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Abstract

The invention relates to a natural hypoglycemic agent capable of exerting hypoglycemic effects by regulating balance of intestinal flora, which belongs to the technical field of traditional Chinese medicine research. The natural hypoglycemic agent is composed of the following substances in weight percentage: 30%-50% of an extracted purifying object of total anthraquinone glycoside, 10%-20% of an extracted purifying object of melicope patulinervia and general flavone, 15%-25% of an extracted purifying object of rodgersia podophylla and polyphenol, 20%-30% of a ginger and cape jasmine extract product. The above-mentioned natural hypoglycemic agent has reasonable product formula, green environmental protection, and good safety, and is suitable for long-term use; through the synergistic improvement of the interaction of the components, the natural hypoglycemic agent can play a good role in protecting the intestinal flora and treating type 2 diabetes; the special composition makes the product have the effect of reducing sugar and lowering lipid, and the product is convenient to take.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine research, and specifically relates to a natural hypoglycemic preparation that exerts hypoglycemic effect by regulating the balance of intestinal flora. Background technique [0002] Diabetes mellitus (Diabetes Mellitus) is a chronic metabolic disease characterized by chronic hyperglycemia caused by insulin deficiency. Diabetes can cause many complications and seriously affect the quality of life and longevity of patients. Due to the complexity of the etiology, modern medical methods cannot completely overcome it, and it is still a lifelong disease. In the current clinical treatment of diabetes in China, traditional medical methods, especially the use of natural products, have played an important role in the treatment of diabetes. In recent years, with the development of social economy and the transformation of lifestyle, the incidence of diabetes has increased significantly, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P1/00A61P3/10
Inventor 袁珂方继莉罗阳
Owner 杭州御寿生物科技有限公司
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