Application of cannabinoid receptor CB1 in retinal photoreceptor cell degenerative diseases

Abstract

The invention relates to application of a cannabinoid receptor CB1 in retinal photoreceptor cell degenerative diseases and belongs to the field of gene functions and application. The invention specifies functions of CB1 in retinal photoreceptor cell degenerative diseases such as RP (retinitis pigmentosa) and AMD (age-related macular degeneration), and meanwhile confirms that an inhibitor SR1 of CB1 is capable of effectively alleviating apoptosis of retinal photoreceptors and protecting functions of the cell, so that a CB1 gene can be used as a medicine target for screening medicines for protecting functions of the retinal photoreceptor cell and / or preventing, relieving and treating retinal photoreceptor cell degenerative diseases such as RP and AMD; and the CB1 gene can be used as a targetgene in gene treatment, can be used for designing and preparing medicines and / or biological reagents for protecting functions of the retinal photoreceptor cell and / or preventing, relieving and treating diseases such as RP and AMD, and provides an effective novel way for treatment on retinal photoreceptor cell degenerative diseases.

Description

technical field [0001] The invention belongs to the field of gene function and application, and relates to the function and application of cannabinoid receptor CB1 and its specific antagonist SR141716A in the treatment of retinal photoreceptor cell degenerative diseases, in particular to drugs for alleviating or treating retinal photoreceptor cell degenerative diseases in the application. Background technique [0002] Retinal photoreceptor cell degenerative diseases are a group of degenerative diseases characterized by progressive photoreceptor cell and pigment epithelial function loss. Such diseases are mainly caused by gene mutations or RPE cell dysfunction. Common typical examples are retinitis pigmentosa (RP) and age-related macular degeneration (AMD), which are also two important and difficult blinding eye diseases. The prevalence of degeneration of photoreceptor cells caused by genetic causes is about 1 / 3500-1 / 4000. There are currently 400,000 patients with retinitis ...

AI Technical Summary

Problems solved by technology

Cannabinoids are known to have neuroprotective effects in central nervous system trauma, neuritis, and neurodegenerative diseases, but the role of cannabinoids and their receptors in chronic retinal degenerative diseases such as RP and AMD is unclear

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