Application of cannabinoid receptor CB1 in retinal photoreceptor cell degenerative diseases
A technology for cannabinoid receptors and degenerative diseases, applied in the field of gene function and application, can solve problems such as the unclear role of cannabinoids, and achieve the effect of protecting cell functions
Inactive Publication Date: 2019-12-10
WUHAN UNIV
View PDF2 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Cannabinoids are known to have neuroprotective effects in central nervous system trauma, neuritis, and neurodegenerative dise
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0030] (1) Reveal that CB1 is widely expressed in retinal tissues.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more PUM
Login to view more Abstract
The invention relates to application of a cannabinoid receptor CB1 in retinal photoreceptor cell degenerative diseases and belongs to the field of gene functions and application. The invention specifies functions of CB1 in retinal photoreceptor cell degenerative diseases such as RP (retinitis pigmentosa) and AMD (age-related macular degeneration), and meanwhile confirms that an inhibitor SR1 of CB1 is capable of effectively alleviating apoptosis of retinal photoreceptors and protecting functions of the cell, so that a CB1 gene can be used as a medicine target for screening medicines for protecting functions of the retinal photoreceptor cell and/or preventing, relieving and treating retinal photoreceptor cell degenerative diseases such as RP and AMD; and the CB1 gene can be used as a targetgene in gene treatment, can be used for designing and preparing medicines and/or biological reagents for protecting functions of the retinal photoreceptor cell and/or preventing, relieving and treating diseases such as RP and AMD, and provides an effective novel way for treatment on retinal photoreceptor cell degenerative diseases.
Description
technical field [0001] The invention belongs to the field of gene function and application, and relates to the function and application of cannabinoid receptor CB1 and its specific antagonist SR141716A in the treatment of retinal photoreceptor cell degenerative diseases, in particular to drugs for alleviating or treating retinal photoreceptor cell degenerative diseases in the application. Background technique [0002] Retinal photoreceptor cell degenerative diseases are a group of degenerative diseases characterized by progressive photoreceptor cell and pigment epithelial function loss. Such diseases are mainly caused by gene mutations or RPE cell dysfunction. Common typical examples are retinitis pigmentosa (RP) and age-related macular degeneration (AMD), which are also two important and difficult blinding eye diseases. The prevalence of degeneration of photoreceptor cells caused by genetic causes is about 1 / 3500-1 / 4000. There are currently 400,000 patients with retinitis ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more Application Information
Patent Timeline
Login to view more IPC IPC(8): A61K45/00A61K31/454A61K38/17A61P9/10A61P27/02
CPCA61K31/454A61K38/1796A61K45/00A61P9/10A61P27/02A61K2300/00
Inventor 沈吟陈媛媛邓琴琴李莹雷新兰罗雪
Owner WUHAN UNIV
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Try Eureka
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap