Solid phase microextraction-high performance liquid chromatography online combined detection method for zoledronic acid and risedronic acid
A technology of high-performance liquid chromatography and risedronic acid, which is applied in the field of solid-phase microextraction-high performance liquid chromatography on-line combined detection, to achieve the effects of cleaning and regeneration, prolonging service life, and enhancing specific interaction
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[0026] (1) Preparation of matrix monolithic column: wash the empty polytetrafluoroethylene tube with chromatographically pure methanol for half an hour, then place it in a 60°C oven to dry; Formaldehyde solution and 0.1mol / L hydrochloric acid solution were mixed uniformly at a volume ratio of 4:5:1, put into a pre-washed polytetrafluoroethylene tube, and reacted in a 55°C water bath for 10 minutes to prepare a urea-formaldehyde resin matrix monolithic column.
[0027] (2) Coating of polydopamine: Wash the urea-formaldehyde resin matrix monolithic column with water for 1 hour through a microinfusion pump to remove unreacted substances in the column; at the same time, take 5mL of 10mmol / L Tris-HCl solution with pH=8.0 and add 10mg of dopamine , after dissolving and mixing, let it stand for 5 minutes to prepare dopamine solution; then, use a microinfusion pump to fill dopamine solution with urea-formaldehyde resin matrix monolithic column; then, both ends of monolithic column are ...
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