Separation substrate, cell separation filter and platelet producing method

A platelet and substrate technology, applied in separation methods, biological material sampling methods, biological preparations for removing bad cells, etc., can solve problems such as difficulty in maintaining the balance between demand and supply

Pending Publication Date: 2019-12-20
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current platelet preparation depends on blood donation from volunteers. Although the effective period of storage is extremely short of 4 days, as the population of the age group who can donate blood due to declining birth rate decreases and the population of elderly people with high blood donation needs increases, Predicting the balance of demand and supply in the medical field is difficult to maintain

Method used

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  • Separation substrate, cell separation filter and platelet producing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118]

[0119] Acetic acid, acetic anhydride, and sulfuric acid are mixed with cellulose (raw material: cotton linter fiber), and acetylation is performed while keeping the reaction temperature at 40° C. or lower. After the cellulose used as a raw material disappears and the acetylation is completed, heating is continued at 40° C. or lower to adjust the desired polymerizability.

[0120] Next, after adding an aqueous acetic acid solution to hydrolyze the remaining acid anhydride, heating is performed at 60° C. or lower to partially hydrolyze and adjust to a desired degree of substitution.

[0121] Residual sulfuric acid was neutralized by an excess of magnesium acetate. Reprecipitation was performed from an aqueous acetic acid solution, followed by repeated washing in water, whereby cellulose acetate with a degree of substitution of 2.91 was synthesized.

[0122]

[0123] Except for changing the acetic acid to a mixed solvent of acetic acid and propionic acid, and changi...

Embodiment 2～5 and comparative example 1

[0148] Except for adjusting the concentration of cellulose acetate and cellulose acetate propionate solution introduced into the nanofiber production apparatus to produce a nonwoven fabric, a separation substrate was produced and evaluated in the same manner as in Example 1. . The results are shown in Table 1.

Embodiment 6～7 and comparative example 2～3

[0150] Except having changed the unit quantity at the time of producing a nonwoven fabric with the nanofiber production apparatus, the separation base material was produced by the method similar to Example 1, and it evaluated. The results are shown in Table 1.

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Abstract

The present invention addresses the problem of providing: a separation substrate which has a high inhibition rate of megakaryocytes and a high permeability of platelets; a cell separation filter usingthe same; and a platelet producing method. The separation substrate of the present invention is composed of a non-woven fabric for separating platelets from cell suspension including megakaryocytes and platelets, wherein the average pore diameter of the separation substrate is 2.0-15.0 [mu]m and the thickness of the separation substrate is 10-500 [mu]m.

Description

technical field [0001] The invention relates to a method for manufacturing a separation substrate, a cell separation filter and platelets. Background technique [0002] Platelets are cells that play a central role in the formation of thrombus and exhibit a hemostatic function in vivo. Therefore, when platelets decrease during bleeding or when anticancer agents are used, it may lead to death in severe cases. [0003] Furthermore, the only established therapy for the reduction of platelets is the transfusion of platelet preparations. The current platelet preparation depends on blood donation from volunteers. Although the preservation period is extremely short of 4 days, as the population of the age group who can donate blood due to declining birth rate decreases and the population of elderly people with high need for blood donation increases, Predicting the balance of demand and supply in the medical field is difficult to maintain. [0004] Therefore, the development of a so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/06C12M1/12C12N5/078
CPCC12M47/02C12M47/04C12M33/14B01D39/18B01D39/1623B01D2239/1216B01D2239/1233B01D2239/1258B01D2221/10B01D2239/0618B01D2239/0636C12M29/04C12N5/0644C12N5/0068C12N5/0087
Inventor 武井俊树山田忠范竹上竜太神长邦行福永昭人金村一秀
Owner FUJIFILM CORP
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