Application of Garlic Veratrine in the Preparation of Drugs for Prevention and Treatment of Candida Albicans Infection

Abstract

The invention aims to disclose the application of allicveratrine in the preparation of medicines for preventing and treating Candida albicans infection. Through the detection of various indicators such as the effect of the compound allicveratrine on the growth of Candida albicans, mycelia inhibition rate, cytotoxicity, and animal models, the results show that allicveratrine has no obvious effect on the growth of Candida albicans, among which, The compound allicilveratrine can still effectively inhibit the mycelium formation of Candida albicans when the concentration is 50 μM, and the mycelium formation rate is lower than 50%. In addition, allicveratrine has a good protective effect on human cell A549 infected by Candida albicans, and the compound allicveratrine itself has no obvious toxic and side effects on cells. In the mouse oral model, garlic veratrine has a good inhibitory effect on the invasion of Candida albicans.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of veratridine alli for preparing a medicine for preventing and treating Candida albicans infection. Background technique [0002] Candida albicans, also known as Candida albicans and Candida albicans, is an opportunistic pathogen that widely exists in nature as well as in the oral cavity, respiratory tract, digestive tract, and vaginal mucosa of the human body. Under normal circumstances, Candida albicans generally does not cause disease, but when the host immunity is low, it can cause deep infection of the body surface and even internal tissues and organs, which is usually difficult to cure. Data show that in immunocompromised patients, the fatality rate of Candida albicans infection is 40%-70%. [0003] Existing studies have shown that the pathogenicity of Candida albicans is related to its yeast-hyphal two-phase transformation. First, the fre...

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Problems solved by technology

However, there is no report on the antibacterial properties of allicveratrine extracted from veratrum

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