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Preparation method of Shuguan granules

A technology for granules and Polygonatum, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problem that the quality of Shuguan granules cannot meet the use requirements, the removal of toxic ingredients is not complete, and the raw materials Low utilization rate and other problems, to achieve the effect of increasing the content of chlorogenic acid, shortening the production cycle and improving the utilization rate

Active Publication Date: 2019-12-31
JIANGXI YINTAO PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the problems of diarrhea and liver toxicity caused by anthraquinone components in Polygonum multiflorum, and the low utilization rate of raw materials such as Wulingzhi stench and Epimedium, the invention provides a preparation method of Shuguan Granules
[0010] The second object of the present invention is to provide a processing method that specifically degrades the anthraquinone components in Polygonum multiflorum without destroying its active ingredient stilbene glycosides, so as to solve the problem of Shuguan granules caused by incomplete removal of toxic components in Polygonum multiflorum in the existing processing process. The quality of the product cannot meet the requirements of use;

Method used

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  • Preparation method of Shuguan granules

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Effect test

Embodiment 1

[0044] A preparation method of Shuguan granule, which is prepared by extracting the following raw materials: Polygonum multiflorum 640.8g, Salvia miltiorrhiza 480g, Polygonatum 640.8g, Rhizoma Chuanxiong 480g, Epimedium 480g, Safflower 480g, Wulingzhi 320.4g made from vinegar , 85% ethanol granulation, appropriate amount of drinking water, wherein the auxiliary materials are composed of sucrose and dextrin, the mass ratio of sucrose and dextrin is 1:2, and the total mass of sucrose and dextrin is 100g;

[0045] The preparation method of Shuguan granule is as follows:

[0046] The processing method of step (1) to make Polygonum multiflorum and Rhizoma Polygonatum is as follows: take fresh Polygonum multiflorum and Rhizoma Polygonatum, wash, slice 1cm, make Polygonum multiflorum and Rhizoma Polygonatum slices, mix well with black soybean juice and steam at 100°C until both inside and outside are brown Brown, or sun-dried until half-dried, dry, use 10Kg of black beans for every 1...

Embodiment 2

[0049] A preparation method of Shuguan granule, which is prepared by extracting the following raw materials: Polygonum multiflorum 640.8g, Salvia miltiorrhiza 480g, Polygonatum 640.8g, Rhizoma Chuanxiong 480g, Epimedium 480g, Safflower 480g, Wulingzhi 320.4g made from vinegar , 85% ethanol granulation, appropriate amount of drinking water, wherein the auxiliary materials are composed of sucrose and dextrin, the mass ratio of sucrose and dextrin is 1:1, and the total mass of sucrose and dextrin is 200g;

[0050] The preparation method of Shuguan granule is as follows:

[0051] The processing method of step (1) for making Polygonum multiflorum and Rhizoma Polygonatum is as follows: take fresh Polygonum multiflorum and Rhizoma Polygonatum, wash and slice 0.8cm into slices, make Polygonum multiflorum and Rhizoma Polygonatum slices, mix well with black soybean juice and steam at 100°C until the inside and outside are uniform. Sepia, or sun-dried until half-dried, dry, use 10Kg of b...

Embodiment 3

[0054] A preparation method of Shuguan granule, which is prepared by extracting the following raw materials: Polygonum multiflorum 640.8g, Salvia miltiorrhiza 480g, Polygonatum 640.8g, Rhizoma Chuanxiong 480g, Epimedium 480g, Safflower 480g, Wulingzhi 320.4g made from vinegar , 85% ethanol granulation, appropriate amount of drinking water, wherein the auxiliary materials are composed of sucrose and dextrin, the mass ratio of sucrose and dextrin is 2:1, and the total mass of sucrose and dextrin is 300g;

[0055] The preparation method of Shuguan granule is as follows:

[0056] The processing method of step (1) to prepare Polygonum multiflorum and Rhizoma Polygonatum is as follows: take fresh Polygonum multiflorum and Rhizoma Polygonatum, wash and slice 0.5cm into slices, make Polygonum multiflorum and Rhizoma Polygonatum slices, mix well with black soybean juice and steam at 100°C until the inside and outside are uniform. Sepia, or sun-dried until half-dried, dry, use 10Kg of b...

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Abstract

The invention provides Shuguan granules. The Shuguan granules are prepared from the following raw material medicines by mass: 640.8 g of radix polygoni multiflori preparata, 480 g of radix salviae miltiorrhizae, 640.8 g of rhizoma polygonati preparata, 480 g of rhizoma chuanxiong, 480 g of herba epimedii, 480 g of flos carthami and 320.4 g of vinegar-processed trogopterus dung; 85% ethanol is added for granulation, an appropriate amount of drinking water is added, ingredients are constituted by sucrose and dextrin, and the mass ratio of the sucrose to the dextrin is (1 to 2):(1 to 2). The invention further discloses a preparation method of the Shuguan granules. Thus the obtained effective component, namely stibene glucoside, in the radix polygoni multiflori preparata is remarkably improved, the content of free anthraquinone is decreased, and meanwhile, the toxic and side effects of the Shuguan granules are reduced by the greatest extent, so that the quality of the Shuguan granules is guaranteed.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method of Shuguan Granules. Background technique [0002] Shuguan granules are composed of 640.8g of Polygonum multiflorum, 480g of Salvia miltiorrhiza, 640.8g of Polygonatum, 480g of Rhizoma Chuanxiong, 480g of Epimedium, 480g of safflower, and 320.4g of vinegar-made Wulingzhi. Add 12 times the amount of water each time, decoct for 3 hours for the first time, decoct for 1 hour each for the second and third times, combine the decoction, filter, and concentrate the filtrate to a relative density of about 1.24 (50°C), add ethanol to make the alcohol The amount reaches 50%, stand still; filter the supernatant, recover ethanol, concentrate to a thick paste, let it cool, and set aside, add stevioside and dextrin to the above clear paste, dry, crush, add ethanol to fine powder to make granules , dried, made into 1000g, that is. Can nourish yin and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/16A61K35/24A61K36/704A61K47/36A61K47/26A61P3/06A61P7/02A61P9/10
CPCA61K9/1623A61K9/1652A61K35/24A61K36/236A61K36/286A61K36/296A61K36/537A61K36/704A61K36/8969A61K2236/10A61K2236/19A61K2236/331A61K2236/39A61K2236/55A61P3/06A61P7/02A61P9/10A61K2300/00
Inventor 李后如吴巍张建荣李旺龙
Owner JIANGXI YINTAO PHARMACEUTICAL CO LTD
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