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Application of andrographolide in preparation of medicines for preventing or/and treating sarcopenia

A technology of andrographolide and drugs, applied in the field of medicine, can solve the problems of muscle strength loss, weight loss, etc., and achieve the effects of preventing and sarcopenia, increasing muscle mass, and strong pharmacological effects

Active Publication Date: 2020-01-17
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a new application of andrographolide for the existing sarcopenia and the problems of decreased muscle strength, fatigue and weak muscle strength caused by aging, obesity, cardiovascular disease or other diseases, etc. That is, the application of andrographolide in the preparation for the prevention and treatment of sarcopenia. Andrographolide has the functions of enhancing muscle strength, increasing muscle weight, improving muscle function, muscle strength and muscle mass, and can be used to prevent and treat sarcopenia , enhance muscle strength, increase muscle mass, reduce the risk of fractures, improve the quality of life, especially the quality of life of the elderly; in addition, andrographolide also has the effect of reducing weight. Sexual efficacy, can be widely used in fitness, bodybuilding

Method used

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  • Application of andrographolide in preparation of medicines for preventing or/and treating sarcopenia
  • Application of andrographolide in preparation of medicines for preventing or/and treating sarcopenia
  • Application of andrographolide in preparation of medicines for preventing or/and treating sarcopenia

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Embodiment 1

[0058] Embodiment 1 prepares andrographolide

[0059] After the medicinal material Andrographis paniculata (1kg) is crushed into coarse powder, add ethanol solution (mass concentration is 75%, usually 50-75%), heat and reflux extraction, the number of times of extraction is 2 times (usually 2-3 times), each time The volume of the ethanol solution during extraction is 5L (usually 5-20L), that is, the volume ratio of the volume of the ethanol solution to the Andrographis paniculata medicinal material is 5-20:1 during each extraction.

[0060] The extract is concentrated under reduced pressure until it has no alcohol smell, and the extract-concentrate is obtained. The temperature of the concentration under reduced pressure is 70°C, and the relative vacuum is -0.09~-0.075MPa. The weight of the extract-concentrate and the raw material The weight ratio of Andrographis paniculata is 1:1 (usually 1-5:1).

[0061] Add activated carbon to the extraction-concentrate, stir, filter after ...

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Abstract

The invention discloses application of andrographolide in preparation of medicines for preventing or / and treating sarcopenia. Andrographolide has an effect of remarkably reinforcing muscle strength and is used for treating or preventing sarcopenia and other muscle strength weakened diseases. Currently, sarcopenia and related diseases lack for treatment medicines with a remarkable curative effect.Experiments prove that the andrographolide has the effects of reinforcing muscle endurance and instantaneous holding strength, has functions of reducing fat and weight, has small toxic and side effects, especially does not influence functions of liver and kidneys, is a safe, efficient and stable medicine or health-protecting product for preventing and treating andrographolide and other muscle strength weakened diseases, control and secondary prevention of muscle related symptoms developed from other diseases and the like, is applicable to industrial production and is easy to popularize. Therefore, a new field is opened for application of the andrographolide, and a new medicine source is provided to prevention and treatment of muscle strength weakened diseases.

Description

technical field [0001] The present invention relates to the field of medicine, relates to a drug or health food for preventing or / and treating sarcopenia, in particular to the application of a traditional Chinese medicine andrographolide in the preparation of drugs or health food for preventing or / and treating sarcopenia. Background technique [0002] Sarcopenia, also known as "sarcopenia", is a progressive age-related syndrome characterized by a decrease in systemic muscle mass and / or muscle strength or a decrease in muscle physiological function. Sexual, widespread musculoskeletal disorders associated with increased likelihood of adverse outcomes from falls, fractures, physical disability, and death. Elderly people are at high risk of sarcopenia and osteoporosis, and these two diseases interact with each other. Sarcopenia includes age-related sarcopenia, muscle symptoms secondary to primary disease, decreased activity, and sarcopenia due to malnutrition. [0003] At pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P21/00A23L33/105
CPCA61K31/365A61P21/00A23L33/105A23V2002/00A23V2200/316
Inventor 胡元会崔翰明师帅张秋燕宋庆桥吴华芹魏艺耿彦婷蒋雨辰
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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