Traditional Chinese medicine incompatibility mining method

Abstract

The invention discloses a traditional Chinese medicine incompatibility mining method. The method comprises the following steps of: S1, collecting traditional Chinese medicine pair data; S2, constructing a traditional Chinese medicine pair network; S3, performing medicine anti-community structure detection in the traditional Chinese medicine pair network through adoption of an anti-community detection algorithm, and dividing the traditional Chinese medicine pair network into a plurality of medicine anti-communities; and S4, for each medicine anti-community, combining the medicines in the medicine anti-communities in pairs to form a plurality of local medicine pairs, mining traditional Chinese medicine incompatibility in the local medicine pairs in a mode of matching the local medicine pairswith known incompatibility medicine pairs, and predicting potential traditional Chinese medicine incompatibility in the local medicine pairs in a screening mode. According to the method, the incompatibility between the traditional Chinese medicines is mined and predicted from the perspective of complex network anti-community detection for the first time, and compared with a mode of searching allthe medicines in the traditional technology, the method performs local searching, so that the searching range is narrowed, the known incompatibility can be efficiently mined, and the potential incompatibility between the medicines can be predicted.

Description

technical field [0001] The invention relates to the technical field of incompatibility of traditional Chinese medicines, in particular to a mining method for incompatibility of traditional Chinese medicines based on complex network local expansion optimization anti-community detection. Background technique [0002] Some single drugs of traditional Chinese medicine have toxic and side effects, and there are also adverse effects between "drug-drugs" of traditional Chinese medicine. For example, clinically, the use of seaweed and licorice together will cause glycyrrhetinic acid to accumulate in the kidneys, inhibit the expression of HSD11B2 in kidney tissues, cause aldosterone-cortisol system disorders, and cause nephrotoxicity [Meng Xian, Wu Zhenhui, Peng Yunru, etc. Seaweed- Discussion on the mechanism of nephrotoxicity in rats induced by anti-drug compatibility of licorice [J]. Pharmacology and Clinics, 2018, 49(9): 2076-2083.]. [0003] The incompatibility of traditional C...

AI Technical Summary

Problems solved by technology

[0008] (1) With regard to medical experimental methods, for different incompatibility, medical experiments must design specific experimental means, and the experimental methods are very different; the medical experimental method that is effective for a certain incompatibility is not suitable for other incompatibility , methods based on medical experiments are not universally applicable

[0009] (2) Regarding the medical experiment method, its operation process is complicated, the experiment costs a lot of money, and it also consumes manpower and material resources; in addition, the medical experiment method can only analyze and excavate the potential causes of the existing incompatibility

[0010] (3) Regarding the data analysis method, it is based on a large number of known incompatibility, excavating the law of drug properties, the compatibility relationship between anti-drugs and the same prescription, and the efficacy relationship between drugs, lacking in-depth mining of the relationship between drugs and the incompatibility between Chinese medicines relationship prediction

Images