DNA library for detecting and diagnosing corneal dystrophy disease-causing genes as well as application of DNA library

Abstract

The invention relates to a DNA library for detecting and diagnosing corneal dystrophy disease-causing genes as well as application of the DNA library. The library comprises 24 disease-causing genes related to corneal dystrophy; 24 corneal dystrophy disease-causing genes are preferably selected, a probe pool is designed, a target area library aiming at the 24 corneal dystrophy disease-causing genesis established, and the library performs sequencing by a high-throughput sequencing technology, looks for disease-cause mutation and provides genetic and molecular biological basis for clinical diagnosis. The library has the characteristics of accuracy, rapidness, flexibility and low cost; 24 gene detection areas can detect various kinds of common corneal dystrophy such as epithelial and subepithelial corneal dystrophy, Bowman's membrane corneal dystrophy, stromal corneal dystrophy, descemet's membrane and corneal endothelium dystrophy; and important significance and clinical value in diagnosis and differential diagnosis on the corneal dystrophy are achieved.

Description

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AI Technical Summary

Benefits of technology

This patented describes methods for identifying specific diseases associated with cornea dysfunction caused by various factors like aging (age) and environmental exposure during eye development. These techniques involve analyzing gene expression levels within certain parts of the body called chromatics, specifically focussing upon different types of cells found inside them. By comparing these results against existing data sources collected over time, it becomes possible to identify new ones without having any previous knowledge about how they were developed. Overall, this approach provides valuable tools for understanding complex disorders involving multiple organs and developing effective treatments for vision loss due to degenerative conditions.

Problems solved by technology

This patented technical problem addressed in the current treatments involves identifying and categorizing coronal degeneraectropica (CD) diseases that may affect their visual function due to changes in color perception such as staining from lens crystals during eye growth phase. Current techniques require subjectivity and interpretation, making them difficult to interpret even if they were able to identify certain types of CD disorders correctly.

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