Method for preparing fecal microbiota transplantation capsule containing benzoylaconine by utilizing human fecal microbiota fermented aconite roots

Abstract

The invention relates to a method for preparing a fecal microbiota transplantation capsule containing benzoylaconine by utilizing human fecal microbiota fermented aconite roots. Fecal microbiota transplantation (FMT) means that a functional flora in healthy human feces is transplanted into gastrointestinal tracts of a patient to re-establish a new intestinal flora so as to realize treatment on intestinal and parenteral diseases. Clinical application discovers that a required curative effect cannot be achieved after certain patients take the prepared aconite roots, one of main reasons causing individual differences is incomplete intestinal flora of the patient, and toxic substances in the prepared aconite roots cannot be normally metabolized into non-toxic active ingredients, the active ingredients have low utilization, and the required curative effect of the prepared aconite roots cannot be achieved. Healthy high-quality feces of a fecal microbiota transplant donor are utilized, are used for simulating intestinal microbes in vitro to achieve an effect of transforming the prepared aconite roots, aconitine and other toxic ingredients in the prepared aconite roots can be transformed into nontoxic metabolitic products through proper fermentation conditions, and the content of benzoylaconine and other active ingredients is increased. The fecal microbiota capsules prepared from fecalmicrobiota fermentation liquid can be used in fecal microbiota transplantation treatment in clinical application.

Description

technical field [0001] The invention belongs to the fields of human fecal bacteria transplantation, fermentation and traditional Chinese medicine, and relates to a method for preparing fecal bacteria transplant capsules containing benzoylaconitine by using human feces bacteria to ferment aconite. Background technique [0002] "Fecal microbiota transplantation" (FMT) refers to the transplantation of functional flora in the feces of healthy people into the gastrointestinal tract of patients to rebuild new intestinal flora and achieve the treatment of intestinal and extraintestinal diseases. As an effective means of rebuilding intestinal flora, fecal microbiota transplantation has been used in various bacterial flora-related diseases such as Clostridium difficile infection, inflammatory bowel disease, intractable constipation, metabolic disease, intestinal immune deficiency, and intestinal allergy. Disease treatment and exploratory research, and is considered a breakthrough med...

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Problems solved by technology

[0006] However, it has been clinically found that some patients cannot achieve the desired curative effect after taking aconite, and there is a possibility of poisoning. One of the main reasons for individual differences is that the intestinal flora of the patients is incomplete, which leads to the abnormal metabolism of aconite into benzoyl aconite. Slightly toxic monolipid alkaloids such as tauyuan alkaloids, so that the curative effect of aconite cannot be exerted