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Application of extracellular vesicles derived from mesenchymal stem cells in the treatment of subarachnoid hemorrhage

A technology of subarachnoid space and microglia, applied in the field of molecular biology, can solve the problems of lack of research on physiological and pathological changes

Active Publication Date: 2020-06-30
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still a lack of research on whether it can play a role in the physiological and pathological changes caused by subarachnoid hemorrhage and related mechanisms

Method used

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  • Application of extracellular vesicles derived from mesenchymal stem cells in the treatment of subarachnoid hemorrhage
  • Application of extracellular vesicles derived from mesenchymal stem cells in the treatment of subarachnoid hemorrhage
  • Application of extracellular vesicles derived from mesenchymal stem cells in the treatment of subarachnoid hemorrhage

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Embodiment

[0065] 1. Experimental animals: Adult male SPF grade SD rats weighing 300-330 g were selected for this study, and the experimental animals were purchased from Jinan Pengyue Experimental Animal Breeding Co., Ltd. They were raised in the SPF grade animal breeding room of Shandong University Animal Center, with a temperature of 20±2°C and a natural light / dark (≈12h-12h) cycle. Animal experimentation protocols were approved by the Animal Care and Use Committee of Shandong University according to the principles outlined in the Guide for the Care and Use of Animals of the National Institutes of Health. Personnel working with animal models received systematic training in accordance with Institutional Animal Care and Use Committee guidelines (IACUC).

[0066] 2. Establishment of SAH model in rats: Rats were anesthetized by isoflurane inhalation anesthesia. The dose of isoflurane inhalation was controlled by an R500 general-purpose small animal anesthesia machine (Shenzhen Ruiwode Lif...

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Abstract

The invention provides an application of extracellular vesicles derived from mesenchymal stem cells in treatment of subarachnoid hemorrhage, which belongs to the technical field of molecular biology.The MSCs extracellular vesicles (MSCs-EVs) have the effects of relieving SAH complications, and improving prognosis and the like. Specifically, the MSCs-EVs can effectively improve the neuroinflammation reaction after subarachnoid hemorrhage (SAH), promote the phenotypic transformation of microglial cells to M2, and relieve the symptoms of neurological impairment, cerebral water content increase and the like caused by subarachnoid hemorrhage.

Description

technical field [0001] The invention belongs to the technical field of molecular biology, and in particular relates to the application of extracellular vesicles derived from mesenchymal stem cells in the treatment of subarachnoid hemorrhage. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily regarded as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Subarachnoid hemorrhage (SAH) is a disease with high mortality. At present, there is a lack of methods to significantly improve the prognosis of patients clinically. Accumulating evidence shows that changes in the microenvironment of brain tissue play an important role in the injury after stroke, especially the inflammatory response. In addition, the severity of the inflammatory res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N5/0775A61K35/28A61P7/04A61P25/00A61P29/00
CPCA61K35/28A61P7/04A61P25/00A61P29/00
Inventor 李刚王贞韩敏薛皓初锡丽辛丹清李婷婷柯鸿飞
Owner SHANDONG UNIV QILU HOSPITAL
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