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Application of extracellular vesicles derived from mesenchymal stem cells in treatment of subarachnoid hemorrhage

A subarachnoid space, microglia technology, applied in the field of molecular biology, can solve problems such as lack of research on physiological and pathological changes

Active Publication Date: 2020-02-07
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still a lack of research on whether it can play a role in the physiological and pathological changes caused by subarachnoid hemorrhage and related mechanisms

Method used

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  • Application of extracellular vesicles derived from mesenchymal stem cells in treatment of subarachnoid hemorrhage
  • Application of extracellular vesicles derived from mesenchymal stem cells in treatment of subarachnoid hemorrhage
  • Application of extracellular vesicles derived from mesenchymal stem cells in treatment of subarachnoid hemorrhage

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Embodiment

[0065] 1. Experimental animals: Adult male SPF-grade SD rats weighing 300-330 g were selected for this study, and the experimental animals were purchased from Jinan Pengyue Experimental Animal Breeding Co., Ltd. It is raised in the SPF animal breeding room of Shandong University Animal Center, the temperature is 20±2℃, and the cycle is natural light / dark (≈12h-12h). The animal experiment protocol was approved by the Animal Care and Use Committee of Shandong University in accordance with the principles outlined in the Animal Care and Use Guide of the National Institutes of Health. Researchers of animal models receive systematic training in accordance with the Institutional Animal Care and Use Committee Guidelines (IACUC).

[0066] 2. Establishment of rat SAH model: Rats were anesthetized with isoflurane inhalation anesthesia. The dose of isoflurane inhalation is controlled by the R500 universal small animal anesthesia machine (Shenzhen Reward Life Technology Co., Ltd.). Take the...

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Abstract

The invention provides an application of extracellular vesicles derived from mesenchymal stem cells in treatment of subarachnoid hemorrhage, which belongs to the technical field of molecular biology.The MSCs extracellular vesicles (MSCs-EVs) have the effects of relieving SAH complications, and improving prognosis and the like. Specifically, the MSCs-EVs can effectively improve the neuroinflammation reaction after subarachnoid hemorrhage (SAH), promote the phenotypic transformation of microglial cells to M2, and relieve the symptoms of neurological impairment, cerebral water content increase and the like caused by subarachnoid hemorrhage.

Description

Technical field [0001] The invention belongs to the technical field of molecular biology, and specifically relates to the application of extracellular vesicles derived from mesenchymal stem cells in the treatment of subarachnoid hemorrhage. Background technique [0002] Disclosure of the background information is only intended to increase the understanding of the overall background of the present invention, and is not necessarily regarded as an acknowledgement or any form of suggestion that the information constitutes the prior art known to those of ordinary skill in the art. [0003] Subarachnoid hemorrhage (SAH) is a disease with high mortality. At present, there is a lack of clinical methods to significantly improve the prognosis of patients. More and more evidences show that changes in the microenvironment of brain tissue play an important role in post-stroke injury, especially inflammation. In addition, the severity of the inflammatory response is related to the prognosis of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61P7/04A61P25/00A61P29/00
CPCA61K35/28A61P7/04A61P25/00A61P29/00
Inventor 李刚王贞韩敏薛皓初锡丽辛丹清李婷婷柯鸿飞
Owner SHANDONG UNIV QILU HOSPITAL
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