Anti-pd-1 antibodies and methods of making and using thereof

A PD-1 and monoclonal antibody technology, applied in the fields of botany equipment and methods, biochemical equipment and methods, chemical instruments and methods, etc.
CN110799537AActive Publication Date: 2020-02-14SYSTIMMUNE INC +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SYSTIMMUNE INC
Publication Date
2020-02-14

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Abstract

The present application provides anti-PD-1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and / or nucleic acids encoding the same, and their use to upregulateT cell function in the treatment of cancer and other T cell dysfunctions to enhance cell-mediated immune responses.
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Description

[0001] Cross References to Related Applications

[0002] This application claims U.S. Provisional Patent Application No. 62545603, filed August 15, 2017, U.S. Provisional Patent Application No. 62524553, filed June 25, 2017, U.S. Provisional Patent Application No. 62524554, filed June 25, 2017 , U.S. Provisional Patent Application No. 62524557, filed June 25, 2017, and U.S. Provisional Patent Application No. 62524558, filed June 25, 2017, which are expressly incorporated herein by reference in their entirety. technical field

[0003] This application generally relates to the field of antibody technology, and more specifically relates to the preparation and use of anti-PD-1 antibodies. Background technique

[0004] Cancer is a major health problem worldwide. In the United States alone, an estimated 1,685,210 new cancer cases were diagnosed and 595,690 deaths occurred in 2016 (http: / / www.cancer.gov). Therefore, any agent that reduces cancer severity or mortality is desirable...

Claims

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