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A detection method of a traditional Chinese medicine composition with sleep-improving function

A detection method and composition technology, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of unfavorable composition internal quality control, no product detection method, and inconvenient operation, so as to reduce the detection cost, The effect of improving the quality control standard and strong specificity of traditional Chinese medicine

Active Publication Date: 2022-03-18
PERFECT CHINA +1
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  • Abstract
  • Description
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Problems solved by technology

[0003] For this reason, Chinese patent literature CN102188610A discloses a kind of traditional Chinese medicine composition with sleep-improving function, including extracts such as ganoderma lucidum, longan meat, jujube seed, cypress kernel, Shouwuteng, Polygonatum, and jujube, but it only introduces the The raw material composition and preparation method of the above-mentioned traditional Chinese medicine composition and the corresponding product testing method are not given, which is not conducive to the internal quality control of the composition in the process of production, circulation and use
In the prior art, there are many detection and analysis methods for Ganoderma lucidum and Shouwu Teng. For example, the Chinese journal document "Research on Quality Control Methods for Minerankang Granules" discloses TLC identification methods for Shouwu Teng and Ganoderma lucidum. Considering two The composition and properties of the medicinal materials are quite different, and it is difficult to identify them under the same conditions at the same time. Therefore, the pretreatment methods for Shouwu Teng and Ganoderma lucidum are different in this method, and the developer systems finally selected are also quite different. The developer selected for the former is For the benzene-ethanol system, the developer used in the latter is petroleum ether (60-90°C)-ethyl formate-formic acid system, which is very inconvenient to operate, especially when a large batch of detection is required, the workload is very large and the work efficiency is very high. Low

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Embodiment 1

[0068] This embodiment 1 provides a kind of quality control method of the traditional Chinese medicine composition with the function of improving sleep, comprising the following steps:

[0069] 1. Identify ganoderma lucidum and Shouwu vine in the Chinese medicine composition with thin-layer chromatography

[0070] Take the traditional Chinese medicine composition for improving sleep function, 5 g of the negative reference substance without the extract of Radix Polygoni Multiflori, 5 g of the negative reference substance without Ganoderma lucidum, 1 g of Ganoderma lucidum extract, and 1 g of Radix Polygoni Multiflori extract, add 30 mL of ethanol, and sonicate for 30 Minutes, filter, evaporate the filtrate to dryness in a water bath, add 1 mL of ethanol to dissolve it, and use it as the test solution, negative control solution and extract solution respectively. In addition, 2 g of Ganoderma lucidum and about 0.25 g of Shouwu Teng reference medicinal materials were taken to make...

Embodiment 2

[0088] This embodiment 2 provides a kind of quality control method of the traditional Chinese medicine composition with the function of improving sleep, comprising the following steps:

[0089] 1. Identify ganoderma lucidum and Shouwu vine in the Chinese medicine composition with thin-layer chromatography

[0090] Take the traditional Chinese medicine composition for improving sleep function, 5 g of the negative control substance without the extract of Shouwu Teng, 5 g of the negative control without Ganoderma lucidum, 1 g of Ganoderma lucidum extract, and 1 g of Shouwu Teng extract, add 20 mL of methanol, and ultrasonicate for 40 Minutes, filter, evaporate the filtrate to dryness in a water bath, add 1.5 mL of propanol to dissolve it, and use it as the test solution, negative control solution and extract solution respectively. In addition, 2 g of Ganoderma lucidum and about 0.25 g of Shouwu Teng reference medicinal materials were taken to make a reference medicinal solution i...

Embodiment 3

[0108] This embodiment 3 provides a kind of quality control method of the traditional Chinese medicine composition with the function of improving sleep, comprising the following steps:

[0109] 1. Identify ganoderma lucidum and Shouwu vine in the Chinese medicine composition with thin-layer chromatography

[0110] Take the traditional Chinese medicine composition for improving sleep function, 5g of the negative control substance without the extract of Radix Polygoni Multiflori, 5g of the negative control substance without Ganoderma lucidum, 1g of Ganoderma lucidum extract, 1g of Radix Radix Polygonum extract, add 40mL of propanol, and perform ultrasonic treatment After 20 minutes, filter, evaporate the filtrate to dryness in a water bath, add 0.5 mL of methanol to dissolve it, and use it as the test solution, negative control solution and extract solution respectively. In addition, 2 g of Ganoderma lucidum and about 0.25 g of Shouwu Teng reference medicinal materials were take...

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Abstract

The invention belongs to the technical field of detection of traditional Chinese medicines, and discloses a detection method of a traditional Chinese medicine composition with the function of improving sleep, including identifying Ganoderma lucidum, Shouwu Teng and Suanzaoren by thin-layer chromatography and measuring spinosin by high-performance liquid chromatography content, the method adopts the same pretreatment method for Ganoderma lucidum and Shouwu Teng, and selects a specific developing agent system, so that various components in Ganoderma lucidum and Shouwu Teng can be well separated, and two kinds of medicinal materials are achieved. Simultaneous identification; In the respective test product chromatograms, on the position corresponding to the positive reference product chromatogram, the spots of the same color are shown, but there is no interference spot in the negative reference product chromatogram, showing that the method of the present invention has stronger specificity . At the same time, the method of the present invention simplifies the operation process, reduces the time required for identification, improves work efficiency, and reduces detection costs. It also provides a new idea for the thin-layer chromatography identification of each component in the traditional Chinese medicine composition, which is beneficial to Improvement of quality control standards for traditional Chinese medicines.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine detection, and in particular relates to a detection method of a traditional Chinese medicine composition capable of improving sleep. Background technique [0002] Sufficient sleep, balanced diet and proper exercise are the three health standards recognized by the international community. One-third of a person's life is spent in sleep. As a necessary process of life, sleep is an indispensable part of health. Sustained sleep disorders can lead to adverse consequences such as physical and mental damage, social and economic losses, including cardiovascular disease, mental disease, low immunity, and even increased mortality, which has become a serious public health problem. [0003] For this reason, Chinese patent literature CN102188610A discloses a kind of traditional Chinese medicine composition with sleep-improving function, including extracts such as ganoderma lucidum, longan ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90G01N30/02G01N30/06
CPCG01N30/90G01N30/02G01N30/06
Inventor 郁晓艺罗文光欧阳道福梁淑明卜闪闪陈晶温馨颜建章孙静胡瑞连
Owner PERFECT CHINA
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