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A drug balloon catheter and its preparation method

A balloon catheter and drug technology, applied in the direction of balloon catheters, catheters, drug devices, etc., can solve the problems of tissue necrosis, waste, poisoning of downstream tissues, etc., to reduce toxic side effects, improve utilization rate, and reduce drug loss Effect

Active Publication Date: 2022-04-15
科睿驰(深圳)医疗科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Only the first part is effectively used by the organization, and the second part of the drug not only causes unnecessary waste, but may also poison downstream tissues and cause tissue necrosis

Method used

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  • A drug balloon catheter and its preparation method
  • A drug balloon catheter and its preparation method
  • A drug balloon catheter and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1. Raw materials:

[0046] 1. Drug: Paclitaxel, Yunnan Hande Biotechnology Co., Ltd.;

[0047] 2. Carrier: PEG1000, Dow Chemical;

[0048] 3. Medical grade ethanol, Shanghai Aladdin Biochemical Technology Co., Ltd.

[0049] 2. Preparation method

[0050] S1, preparing a low-drug content coating solution, weighing 100 mg of paclitaxel and 100 mg of PEG1000 respectively, and dissolving them in 10 ml of medical grade ethanol to obtain a low-drug content coating solution, wherein the ratio of the drug to the mass of the solute is 50%.

[0051] S2, preparing a coating solution with high drug content, weighing 160 mg of paclitaxel and 40 mg of PEG1000 respectively, and dissolving them in 10 ml of medical grade ethanol to obtain a coating solution with high drug content, wherein the ratio of drug to solute mass is 80%.

[0052] S3, by means of ultrasonic spraying, the coating solution with low drug content is first sprayed on the surface of the balloon, sprayed twice, and a...

Embodiment 2

[0057] 1. Raw materials:

[0058] 1. Drug: rapamycin, Fujian Kerui Pharmaceutical Co., Ltd.;

[0059] 2. Carrier: lecithin, Shanghai Aladdin Biochemical Technology Co., Ltd.;

[0060] 3. Medical grade ethanol, Shanghai Aladdin Biochemical Technology Co., Ltd.

[0061] 2. Preparation method

[0062] S1, prepare coating solution with low drug content, take by weighing 20mg rapamycin and lecithin of 180mg respectively, dissolve in the medical grade ethanol of 10ml, obtain the coating solution with low drug content, wherein the ratio of drug to solute mass is 10%.

[0063] S2, preparing a coating solution with high drug content, weighing 100 mg rapamycin and 100 mg lecithin respectively, dissolving them in 10 ml of medical grade ethanol to obtain a coating solution with high drug content, wherein the ratio of drug to solute mass 50%.

[0064] S3, by means of ultrasonic spraying, the coating solution with low drug content is firstly sprayed onto the proximal and distal areas o...

Embodiment 3

[0068] 1. Raw materials:

[0069] 1. Drug: Tacrolimus, Fujian Kerui Pharmaceutical Co., Ltd.;

[0070] 2. Carrier: polyvinylpyrrolidone, Shanghai Aladdin Biochemical Technology Co., Ltd.;

[0071] 3. Medical grade ethanol, Shanghai Aladdin Biochemical Technology Co., Ltd.

[0072] 2. Preparation method

[0073] S1, preparing a low-drug content coating solution, weighing 120 mg of tacrolimus and 80 mg of polyvinylpyrrolidone, respectively, and dissolving them in 10 ml of medical grade ethanol to obtain a low-drug content coating solution, wherein the ratio of drug to solute mass 60%.

[0074] S2, preparing a coating solution with high drug content, weighing 200 mg of tacrolimus and dissolving it in 10 ml of medical grade ethanol to obtain a coating solution with low drug content, wherein the ratio of drug to solute mass is 100%.

[0075] S3, using the method of ultrasonic spraying, spraying the coating solution with low drug content on the surface of the balloon, spraying i...

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Abstract

The invention discloses a drug balloon catheter, which belongs to the field of medical equipment and advanced manufacturing. A drug balloon catheter, comprising a balloon and at least one drug coating covering the surface of the balloon; the drug coating is divided into a low drug content coating and a high drug content coating, and the high drug content coating is composed of an active drug, or The active drug and the carrier are composed, and the low drug content coating is composed of the active drug and the carrier. The advantages of the present invention are as follows: the drug balloon catheter provided by the present invention has multiple coatings with different drug contents, which can effectively reduce the drug loss during the delivery of the drug balloon during the operation, and reduce the amount of drug on the outermost layer and the distal end of the balloon. Loss of drug, as well as drug residues on the surface and proximal end of the balloon during withdrawal of the drug balloon after surgery, reduce drug damage to non-target lesions.

Description

technical field [0001] The invention relates to a drug balloon catheter and a preparation method thereof, belonging to the technical field of medical equipment and advanced manufacturing. Background technique [0002] Percutaneous transluminal angioplasty (PTA) has gone through the stages of bare balloon, bare metal stent, drug-eluting stent, and drug-coated balloon since the 1970s. Among them, Drug Coated Balloon (DCB), on the one hand, drugs can effectively inhibit the excessive proliferation of smooth muscle cells to reduce the incidence of restenosis; The risk of stent thrombosis is reduced, the time of dual antiplatelet is shortened, and the risk of bleeding is reduced. In addition, in clinical studies of coronary artery disease, DCB has shown better efficacy and safety in the treatment of in-stent restenosis, small vessel disease, bifurcation disease, and DCB is also suitable for patients with high bleeding risk, taking oral Patients on anticoagulant drugs or who hav...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M25/10
CPCA61M25/1002A61M25/1027A61M25/1029A61M2025/1031A61M2025/105A61M2205/0238A61M2207/00A61M25/104
Inventor 胡军卢金华孙宏涛孙蓬车海波
Owner 科睿驰(深圳)医疗科技发展有限公司
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