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Application of isobiflorin or its pharmaceutically acceptable salt in preparation of antidepressant pharmaceutical composition

A composition and anti-depressant technology, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effects of definite curative effect, high patient acceptance, and good development prospects

Active Publication Date: 2021-08-31
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current antidepressant drug compositions are no longer limited to tricyclic and tetracyclic drugs, and new antidepressant drug compositions have been continuously validated clinically, but they are still limited in terms of target, system, safety, and adverse reactions. , tolerance, rapid and effective research needs to be strengthened

Method used

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  • Application of isobiflorin or its pharmaceutically acceptable salt in preparation of antidepressant pharmaceutical composition
  • Application of isobiflorin or its pharmaceutically acceptable salt in preparation of antidepressant pharmaceutical composition
  • Application of isobiflorin or its pharmaceutically acceptable salt in preparation of antidepressant pharmaceutical composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The separation of embodiment 1 isobiflorin

[0033] Grind dried cloves (Syzygium aromaticum) into powder, add 70% ethanol at a ratio of 1:10 to liquid, extract twice in a water bath at 60°C for 2 hours each time, and then evaporate the solvent in vacuum. The 70% ethanol extract was suspended in water, and extracted with n-hexane, ethyl acetate and n-butanol in sequence. The n-butanol-soluble fraction was chromatographed on HP-20 and eluted with a water-methanol gradient to obtain several fractions. One of the fractions was further eluted with a water-methanol system (3:7), and then the fraction was recrystallized in methanol to isolate the compound isobiflorin.

Embodiment 2

[0034] Embodiment 2 pharmacodynamics and pharmacology experiment

[0035] 1. Experimental animals: Male ICR mice were purchased from Shanghai Slack Experimental Animal Center, weighing 22-26g, 6 weeks old; the animals were placed in cages of 320×180×160cm, 4 per cage, and the mice were acclimated to the environment for one week; During the whole experiment, the mice were given free access to water and food, the ambient temperature was 22±2°C, the relative humidity was 55±5%, and the light was 12 hours a day.

[0036] 2. Dosage: The dosage of Isobiflorin is respectively low-dose group (20mg / kg), middle-dose group (40mg / kg) and high-dose group (80mg / kg). Isobiflorin was administered by intragastric administration, and the positive drug was fluoxetine hydrochloride (20mg / kg). After the administration, the mice will be used for relevant behavioral experiments and determination of biochemical indicators.

[0037] 3. Forced swimming test: put mice into a cylindrical glass containe...

Embodiment 3I

[0048] The preparation of embodiment 3Isobiflorin tablet

[0049] Prescription (100 capsules): Isobiflorin 0.1g, micronized silica gel 0.5g, lactose 10g, microcrystalline cellulose 10g, sodium carboxymethyl starch 0.05g, magnesium stearate 0.08g, hydroxypropyl methylcellulose 0.1g.

[0050] Preparation method: Mix isobiflorin and micropowder silica gel evenly and micronize; add hydroxypropyl methylcellulose to prepare an adhesive; mix lactose, microcrystalline cellulose and sodium carboxymethyl starch; mix the above main ingredients and The excipients are mixed and dried, then magnesium stearate is added to the granules, mixed evenly, and compressed to make 100 tablets with consistent content (each containing 1 mg of isobiflorin). The recommended oral dosage for adults is 1-2 capsules / time, 1-2 times a day.

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Abstract

The invention discloses the application of isobiflorin or its pharmaceutically acceptable salt derived from qi-regulating medicine in the preparation of antidepressant drug composition. The isobiflorin of the present invention has definite curative effect on treating depression. As a natural medicine derived from clove, it has a long history of use, high safety, high acceptance by patients, and has a good development prospect.

Description

technical field [0001] The invention belongs to the technical field of natural medicine extracts, and in particular relates to the application of isobiflorin or a pharmaceutically acceptable salt thereof in the preparation of antidepressant pharmaceutical compositions. Background technique [0002] Depression is one of the most prevalent mental disorders in the world, directly causing serious public health problems. According to the report of the World Health Organization, depression affects about 17% of people in the world, and more than 1 million people commit suicide due to depression every year. With the rapid development of modern society, people are facing increasing pressure from work, study and life, and the incidence rate of the population is also increasing year by year. In addition, there are differences in depression among individuals, and many factors such as biology, heredity, psychological quality, social relationship and environment also have an impact on th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P25/24
CPCA61K31/7048A61P25/24
Inventor 易立涛李成付刘青程杰
Owner HUAQIAO UNIVERSITY
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