Zanthoxylum bungeanum leaf volatile oil nanoemulsion bacteriostatic and anti-inflammatory spray and preparation method thereof

A technology of prickly ash leaves and volatile oil, applied in aerosol delivery, topical antibacterial agents, pharmaceutical formulations, etc., can solve the problems of low development and utilization rate, and achieve the effects of being convenient to carry, enhancing drug efficacy, and improving bioavailability

Active Publication Date: 2020-04-03
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on Zanthoxylum bungeanum at home and abroad is mainly concentrated on the peel, but as a by-product of Zanthoxylum bungeanum, the annual output is huge, but its development and utilization rate is relatively low.

Method used

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  • Zanthoxylum bungeanum leaf volatile oil nanoemulsion bacteriostatic and anti-inflammatory spray and preparation method thereof
  • Zanthoxylum bungeanum leaf volatile oil nanoemulsion bacteriostatic and anti-inflammatory spray and preparation method thereof
  • Zanthoxylum bungeanum leaf volatile oil nanoemulsion bacteriostatic and anti-inflammatory spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Dahongpao Zanthoxylum bungeanum volatile oil nanoemulsion antibacterial and anti-inflammatory spray

[0028] A nano-emulsion antibacterial and anti-inflammatory spray of Zanthoxylum volatile oil. The preparation process is as follows: (1) Wash 500g of Zanthoxylum bungeanum leaves, dry them in an oven at 35°C for 4 hours, and extract the Zanthoxylum bungeanum leaves by steam distillation after crushing. Volatile oil. Put Dahongpao pepper leaves in a distillation pot, inject an appropriate amount of 1L distilled water to soak for 25 hours, distillation power 1000w, extraction time 2 hours, collect the distillate, put it in an oil-water separator to separate the oil layer, and obtain light yellow, clear and transparent without impurities Dahongpao pepper leaf volatile oil;

[0029] (2) The pomegranate seed oil was extracted by supercritical extraction. 300 g of pomegranate seeds were cleaned and dried in an oven at 35°C for 4 hours, crushed and ground, passed th...

Embodiment 2

[0032] Embodiment 2 rattan pepper leaf volatile oil nanoemulsion antibacterial and anti-inflammatory spray

[0033] (1) Take 800g of rattan pepper leaves, wash them, dry them in an oven at 35°C for 4 hours, and extract the volatile oil of rattan pepper leaves by steam distillation after crushing. Put the pepper leaves in a distillation pot, inject an appropriate amount of 1.6L distilled water to soak for 30 hours, the distillation power is 1000w, and the extraction time is 3.2 hours. Vine pepper leaves volatile oil.

[0034] (2) The pomegranate seed oil was extracted by supercritical extraction. 500 g of pomegranate seeds were cleaned and dried in an oven at 35°C for 4 hours, crushed and ground, passed through a 40-mesh sieve, weighed and sealed. Set the supercritical extractor temperature to 38°C, extraction pressure to 29Mpa, CO2 The flow rate is 11L / h, the separation temperature is 45°C, the separation pressure is 11Mpa, and the extraction time is 4h.

[0035] (3) Take 10...

Embodiment 3 9

[0037] Example 3 Nine-leaf Green Zanthoxylum bungeanum leaf volatile oil nano-emulsion antibacterial and anti-inflammatory spray

[0038] (1) Take 1200g of Zanthoxylum bungeanum leaves, wash them, dry them in an oven at 35°C for 4 hours, grind them, and extract the volatile oil from Zanthoxylum bungeanum leaves by steam distillation. Put the pepper leaves in a distillation pot, inject an appropriate amount of 2.5L distilled water to soak for 35 hours, distill power 1000w, extract for 5 hours, collect the distillate, put it in an oil-water separator to separate the oil layer, and obtain light yellow, clear and transparent nine Yeqing Zanthoxylum volatile oil.

[0039] (2) The pomegranate seed oil was extracted by supercritical extraction. 800 g of pomegranate seeds were cleaned, dried in an oven at 35°C for 4 hours, crushed and ground, passed through a 40-mesh sieve, weighed and sealed. Set the supercritical extractor temperature to 40°C, extraction pressure to 30Mpa, CO 2 Th...

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Abstract

The invention discloses a zanthoxylum bungeanum leaf volatile oil nanoemulsion spray for skin for bacteriostasis and inflammation diminishing and a preparation method thereof. Zanthoxylum bungeanum leaves are used as a main raw material, and zanthoxylum bungeanum leaf volatile oil is extracted by a steam distillation method; a small amount of pomegranate seed oil is used as an oil phase to preparea blank nanoemulsion, and then the blank nanoemulsion is encapsulated with zanthoxylum bungeanum leaf volatile oil to finally prepare the nanoemulsion spray preparation. The nano-emulsion spray utilizes the antibacterial and anti-inflammatory synergistic effects of the zanthoxylum bungeanum leaf volatile oil and the pomegranate seed oil, has the advantages of small particle size, good stability,good solubility, synergistic and slow-release effects and the like, and atomized drug molecules are more beneficial to skin absorption and do not generate drug resistance.

Description

technical field [0001] The invention relates to an antibacterial and anti-inflammatory spray and a preparation method thereof, in particular to a nano-emulsion antibacterial and anti-inflammatory spray of prickly ash leaf volatile oil and a preparation method thereof. Background technique [0002] Zanthoxylum bungeanum Maxim is a small deciduous tree belonging to Rutaceae and Zanthoxylum genus. It has the functions of warming the middle and dispelling cold, dehumidifying and relieving pain, sterilizing and relieving itching, and reducing inflammation. It has a long history of use in my country. Zanthoxylum bungeanum is widely distributed in my country, with a long history of cultivation, and many improved varieties have been formed. At present, the most cultivated varieties include Dahongpao, rattan pepper, and Jiuyeqing. At present, the research on Zanthoxylum bungeanum mainly focuses on the pericarp at home and abroad, but as a by-product of Zanthoxylum bungeanum, the annu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/10A61K36/758A61K47/44A61P31/02A61P19/02C11B9/00
CPCA61K9/0014A61K9/1075A61K36/758A61K36/185A61K47/44A61P31/02A61P19/02C11B9/0015C11B9/0034C11B9/0049A61K9/12A61K2236/331A61K2236/37A61K2300/00
Inventor 颜军汪锡佳何钢刘嵬刘坤平梁立林佳丽
Owner CHENGDU UNIV
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