A kind of pepper leaf volatile oil nanoemulsion antibacterial and anti-inflammatory spray and preparation method thereof

A technology of prickly ash leaves and volatile oil, applied in aerosol delivery, topical antibacterial agents, pharmaceutical formulations, etc., can solve problems such as low development and utilization rate, and achieve the effects of being convenient to carry, relieve arthritis, and easy to use

Active Publication Date: 2022-04-01
CHENGDU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on Zanthoxylum bungeanum at home and abroad is mainly concentrated on the peel, but as a by-product of Zanthoxylum bungeanum, the annual output is huge, but its development and utilization rate is relatively low.

Method used

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  • A kind of pepper leaf volatile oil nanoemulsion antibacterial and anti-inflammatory spray and preparation method thereof
  • A kind of pepper leaf volatile oil nanoemulsion antibacterial and anti-inflammatory spray and preparation method thereof
  • A kind of pepper leaf volatile oil nanoemulsion antibacterial and anti-inflammatory spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Dahongpao Zanthoxylum bungeanum volatile oil nanoemulsion antibacterial and anti-inflammatory spray

[0028] A nano-emulsion antibacterial and anti-inflammatory spray of Zanthoxylum volatile oil. The preparation process is as follows: (1) Wash 500g of Zanthoxylum bungeanum leaves, dry them in an oven at 35°C for 4 hours, and extract the Zanthoxylum bungeanum leaves by steam distillation after crushing. Volatile oil. Put Dahongpao pepper leaves in a distillation pot, inject an appropriate amount of 1L distilled water to soak for 25 hours, distillation power 1000w, extraction time 2 hours, collect the distillate, put it in an oil-water separator to separate the oil layer, and obtain light yellow, clear and transparent without impurities Dahongpao pepper leaf volatile oil;

[0029] (2) The pomegranate seed oil was extracted by supercritical extraction. 300 g of pomegranate seeds were cleaned and dried in an oven at 35°C for 4 hours, crushed and ground, passed th...

Embodiment 2

[0032] Embodiment 2 rattan pepper leaf volatile oil nanoemulsion antibacterial and anti-inflammatory spray

[0033] (1) Take 800g of rattan pepper leaves, wash them, dry them in an oven at 35°C for 4 hours, and extract the volatile oil of rattan pepper leaves by steam distillation after crushing. Put the pepper leaves in a distillation pot, inject an appropriate amount of 1.6L distilled water to soak for 30 hours, the distillation power is 1000w, and the extraction time is 3.2 hours. Vine pepper leaves volatile oil.

[0034] (2) The pomegranate seed oil was extracted by supercritical extraction. 500 g of pomegranate seeds were cleaned, dried in an oven at 35°C for 4 hours, crushed and ground, passed through a 40-mesh sieve, weighed and sealed. Set the temperature of the supercritical extractor at 38°C, the extraction pressure at 29Mpa, and the CO2 The flow rate is 11L / h, the separation temperature is 45°C, the separation pressure is 11Mpa, and the extraction time is 4h.

[0...

Embodiment 3 9

[0037] Example 3 Nine-leaf Green Zanthoxylum bungeanum leaf volatile oil nano-emulsion antibacterial and anti-inflammatory spray

[0038] (1) Take 1200g of Zanthoxylum bungeanum leaves, wash them, dry them in an oven at 35°C for 4 hours, grind them, and extract the volatile oil from Zanthoxylum bungeanum leaves by steam distillation. Put the pepper leaves in a distillation pot, inject an appropriate amount of 2.5L distilled water to soak for 35 hours, distill power 1000w, extract for 5 hours, collect the distillate, put it in an oil-water separator to separate the oil layer, and obtain light yellow, clear and transparent nine Yeqing Zanthoxylum volatile oil.

[0039] (2) The pomegranate seed oil was extracted by supercritical extraction. 800 g of pomegranate seeds were cleaned, dried in an oven at 35°C for 4 hours, crushed and ground, passed through a 40-mesh sieve, weighed and sealed. Set the supercritical extractor temperature to 40°C, extraction pressure to 30Mpa, CO 2 Th...

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Abstract

The invention discloses a Zanthoxylum volatile oil nano-emulsion spray for antibacterial and anti-inflammatory skin and a preparation method thereof. The invention uses Zanthoxylum as the main raw material and extracts the Zanthoxylum volatile oil through steam distillation; a small amount of pomegranate The seed oil was used as the oil phase to prepare a blank nanoemulsion, encapsulate the volatile oil of pepper leaves, and finally make a nanoemulsion spray preparation. This nanoemulsion spray utilizes the synergistic effect of antibacterial and anti-inflammatory effects of the volatile oil of pepper leaves and pomegranate seed oil. It has the advantages of small particle size, good stability, good solubility, synergistic and slow release, and the atomized drug molecules are more conducive Absorbed through the skin without developing drug resistance.

Description

technical field [0001] The invention relates to an antibacterial and anti-inflammatory spray and a preparation method thereof, in particular to a nano-emulsion antibacterial and anti-inflammatory spray of prickly ash leaf volatile oil and a preparation method thereof. Background technique [0002] Zanthoxylum bungeanum Maxim is a small deciduous tree belonging to Rutaceae and Zanthoxylum genus. It has the functions of warming the middle and dispelling cold, dehumidifying and relieving pain, sterilizing and relieving itching, and reducing inflammation. It has a long history of use in my country. Zanthoxylum bungeanum is widely distributed in my country, with a long history of cultivation, and many improved varieties have been formed. At present, the most cultivated varieties include Dahongpao, rattan pepper, and Jiuyeqing. At present, the research on Zanthoxylum bungeanum mainly focuses on the pericarp at home and abroad, but as a by-product of Zanthoxylum bungeanum, the annu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K9/10A61K36/758A61K47/44A61P31/02A61P19/02C11B9/00
CPCA61K9/0014A61K9/1075A61K36/758A61K36/185A61K47/44A61P31/02A61P19/02C11B9/0015C11B9/0034C11B9/0049A61K9/12A61K2236/331A61K2236/37A61K2300/00
Inventor 颜军汪锡佳何钢刘嵬刘坤平梁立林佳丽
Owner CHENGDU UNIV
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