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Application of sophorose in preparation of products for preventing and treating obesity and corresponding products

A technology of obesity and sophorose, applied in the application of sophorose in the preparation of obesity prevention and treatment products and corresponding products, can solve problems such as adverse effects, and achieve good effects and mild regulatory effects

Inactive Publication Date: 2020-04-03
ZHEJIANG HUAKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent uses microorganisms to prevent and treat obesity from the perspective of blocking fatty acid absorption, but it involves mutations in microbial strains that can absorb free fatty acids, and the mutations are not directional
In addition, the patented method involves the transplantation of a single strain, which may cause adverse effects
The patent with the publication number CN101094689B discloses a method for treating obesity and obesity-related diseases and diseases, using anti-obesity agents directed to the forebrain and anti-obesity agents directed to the hindbrain in combination, involving various polypeptide substances, such as PYY (3-36) agonist Agents, NPY5 antagonists, directly acting on the forebrain or hindbrain, there is a certain risk

Method used

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  • Application of sophorose in preparation of products for preventing and treating obesity and corresponding products
  • Application of sophorose in preparation of products for preventing and treating obesity and corresponding products
  • Application of sophorose in preparation of products for preventing and treating obesity and corresponding products

Examples

Experimental program
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Effect test

Embodiment 1

[0030] 1. The source of sophorose

[0031] The sophorose involved in the following examples can be purchased or self-made, and can be prepared by the following method: dissolve 10 g of steviol glycoside (98%) in 20-80 mL of formic acid solution, stir and react at 80 ° C for 30-40 minutes, and vacuum rotary steam Remove the reaction solvent, wash the obtained precipitate with 100mL ultrapure water, filter with suction, discard the precipitate, spin evaporate again, dissolve with 100mL ultrapure water, and keep the supernatant. The obtained solution was separated by a diatom-activated carbon chromatography column, followed by gradient elution with ultrapure water and 5v / v%-30v / v% ethanol solution, and the obtained solution was detected by HPLC. The solution was passed through a 0.22μm filter membrane, chromatographic conditions: chromatographic column: BioRad HPX-87H (300mm*7.5mm), detector: differential refractive index detector, temperature: 55°C, mobile phase: 5mM sulfuric ac...

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Abstract

The invention discloses an application of sophorose in preparation of products for preventing and treating obesity. The invention further discloses corresponding products of the sophorose. According to the application and the corresponding products, the sophorose is used for lowering appetite and properly stimulating generation of short-chain fatty acids so as to achieve the effect of controllingbody weight; and the regulating and controlling action is relatively moderate and is relatively good in acting effect, and direct acting on a brain, acceptors or enzymes is avoided, so that compared with other drugs, the products do not have side effects, can be eaten as part of daily meals and can also be applied to drugs for preventing and treating obesity patients. The sophorose can also be used for weakening adverse effects such as fasting blood-glucose rising and impaired glucose tolerance dose resulting from high-fat meals.

Description

technical field [0001] The invention relates to the technical field of obesity prevention and treatment, in particular to the application of sophorose in the preparation of obesity prevention and treatment products and corresponding products. Background technique [0002] Sophorose is a disaccharide formed by connecting two glucose through β-1,2-glucosidic bonds. It is expensive, only reagent grade, and has no industrial production. Due to the small production amount and high price of sophorose, it cannot be widely used in research. Now it is mainly used to induce Aspergillus or Trichoderma to produce cellulase, and its inducing effect is tens to thousands of times that of other inducing compounds such as lactose. A strong inducer. The molecular weight of steviol glycoside is 804.9, and the sophorose group at the C13 position accounts for 42% of the total molecular weight. It can be seen that in stevioside, sophorose accounts for a high proportion. According to the existing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7016A61P3/04A23L33/125
CPCA61K31/7016A61P3/04A23L33/125A23V2002/00
Inventor 石丽华李勉陈德水左齐乐朱炫
Owner ZHEJIANG HUAKANG PHARMA
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