Method for determining content of 1, 2-hexanediol in cosmetics

Abstract

The invention provides a method for determining the content of 1, 2-hexanediol in cosmetics, and belongs to the field of cosmetic component analysis and detection. The method comprises the following steps: preparing 1, 2-hexanediol standard substances into standard solutions with different concentrations, detecting the standard solutions by adopting a gas chromatography method, and determining a linear relationship between the concentration of 1, 2-hexanediol and a peak area; pretreating the cosmetics to prepare a sample solution; detecting a sample solution by adopting the same gas chromatography, the content of 1, 2-hexanediol in cosmetics is quantitatively calculated by adopting an external standard method, a detector adopted by the gas chromatography is an FID hydrogen flame detector,hydrogen and air are respectively used as auxiliary gas, and a polyethylene glycol capillary chromatographic column is used as a chromatographic column. The method is simple in operation and calculation, good in precision, high in sensitivity, high in recovery rate, good in reproducibility and good in linear fitting, the standard curve correlation coefficient reaches 0.999 or above, and the methodis suitable for detection and analysis of most cosmetics containing 1, 2-hexanediol on market.

Description

technical field [0001] The invention belongs to the field of analysis and detection of cosmetic components, and relates to a method for determining the content of 1,2-hexanediol in cosmetics. Background technique [0002] 1,2-Hexanediol is an important polyol chemical raw material, which is mostly used in the ink of color inkjet printers, advanced cosmetics and synthetic raw materials in the pharmaceutical industry. Adding 1,2-hexanediol to cosmetics has the effect of sterilizing and moisturizing, and when its added amount reaches about 5wt%, it has antiseptic effect, and at the same time, it will not have negative effects on human health. Adding 1,2-Hexanediol to deodorants and antiperspirants is more excellent in deodorant and antiperspirant, and has better skin feeling and transparency, and is mild to the skin. Aussie of the United States added 1,2-hexanediol to the eyelid scrub solution, and Givaudan Co., Ltd. and Japan Co., Ltd. FANCL also added 1,2-hexanediol to skin ...

AI Technical Summary

Problems solved by technology

[0003] At present, there are many kinds of methods for detecting the content of 1,2-hexanediol in cosmetics, and the test conditions involved are different, but these detection methods still cannot meet the market demand for the detection of 1,2-hexanediol in cosmetics. In the calibration quantitative method, it is difficult to choose a suitable internal standard substance because the internal standard substance is not well mixed in the sample, the reaction between the internal standard substance and the sample component, the purity of the internal standard substance is variable, and other factors will affect the detection results. In particular, isotope-labeled internal standards with similar behaviors have certain limitations for the detection of cosmetics in many complex organisms

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