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Blumea balsamifera lipidosome

The technology of oil liposome and aina sesame oil, which is applied in the field of medicine, can solve the problems of no aina sesame oil liposome, decrease of liposome encapsulation rate, large loss of liposome, etc., and achieves high encapsulation rate, The effect of improving compatibility and improving activity

Active Publication Date: 2020-04-10
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method has higher requirements on instruments, and the amount of loss of liposomes in the preparation process is relatively large. Circulation homogenization will also cause the encapsulation efficiency of liposomes to decrease, and the drug contained in liposomes will become less, so it will enter the body to play a role. The efficacy of the drug will decrease accordingly
In addition, the pharmacological effects of the composition in this document are to load skin care essence, regulate sebaceous glands, and clean the skin. In addition, there is no further description of other pharmacological effects
[0007] Therefore currently there is no simple, stable and effective process for preparing Aina balm liposomes, and simply using Aina balm liposomes can effectively treat various skin diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] An Aina sesame oil liposome, the formula of the Aina sesame oil liposome is composed of the following substances in parts by mass: Aina sesame oil 0.538%, soybean lecithin 2.1%, cholesterol 0.304%, and the balance is PBS solution;

[0036] Described Aina sesame oil liposome is made according to the following steps:

[0037] (1) Prepare PBS solution: 0.1 mol / L potassium dihydrogen phosphate and 0.1 mol / L disodium hydrogen phosphate are prepared in a volume ratio of 9:1, and the pH value is 5.6;

[0038] (2) Preparation of dissolving solution: Weigh the formula amount of lecithin, cholesterol and Aina sesame oil and add it to the absolute ethanol whose volume is 1 / 3 of the PBS solution, stir until the lecithin, cholesterol and Aina sesame oil are completely dissolved to obtain a solution ;

[0039] (3) Preparation of liposomes: Inject the solution into the PBS solution at 35-45°C at a rate of 2mL / min, place it in an environment of 40°C and stir at a constant temperature ...

Embodiment 2

[0044] An Aina sesame oil liposome, the formula of the Aina sesame oil liposome is composed of the following substances in parts by mass: 0.45% of Aina sesame oil, 1.7% of soybean lecithin, 0.3% of cholesterol, and the balance is PBS solution;

[0045] Described Aina sesame oil liposome is made according to the following steps:

[0046] (1) Prepare PBS solution: 0.1 mol / L potassium dihydrogen phosphate and 0.1 mol / L disodium hydrogen phosphate are prepared in a volume ratio of 9:1, and the pH value is 5.8;

[0047] (2) Preparation of dissolving solution: Weigh the formula amount of lecithin, cholesterol and Aina sesame oil and add it to the absolute ethanol whose volume is 1 / 4 of the PBS solution, stir until the lecithin, cholesterol and Aina sesame oil are completely dissolved to obtain a solution ;

[0048] (3) Preparation of liposomes: Inject the solution into the PBS solution at 35°C at a rate of 1.8mL / min, place it in a 45°C environment and stir at a constant temperature...

Embodiment 3

[0053] An Aina sesame oil liposome, the formula of the Aina sesame oil liposome is composed of the following substances in parts by mass: 0.55% of Aina sesame oil, 2.7% of soybean lecithin, 0.4% of cholesterol, and the balance is PBS solution;

[0054] Described Aina sesame oil liposome is made according to the following steps:

[0055] (1) Prepare PBS solution: 0.1 mol / L potassium dihydrogen phosphate and 0.1 mol / L disodium hydrogen phosphate are prepared at a volume ratio of 9.2:1, and the pH value is 5.7;

[0056] (2) Preparation of dissolving solution: Weigh the formula amount of lecithin, cholesterol and Aina sesame oil and add it to the absolute ethanol whose volume is 1 / 3 of the PBS solution, stir until the lecithin, cholesterol and Aina sesame oil are completely dissolved to obtain a solution ;

[0057] (3) Preparation of liposomes: Inject the solution into the PBS solution at 35°C at a rate of 2.2mL / min, place it in a 35°C environment and stir at a constant temperatu...

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Abstract

The invention relates to the field of medicine and daily chemical products, in particular to blumea balsamifera liposome. The blumea balsamifera lipidosome is prepared from the following substances inparts by mass: 0.35 to 0.65 percent of blumea balsamifera oil, 1.0 to 3.0 percent of lecithin, 0.2 to 0.5 percent of cholesterol and the balance of a PBS solution. The blumea balsamifera lipidosome can be matched with acceptable auxiliary materials in the fields of medicines and daily chemicals to be further prepared into products such as gels, ointments, eye ointments, liniments, aerosols, solutions, sols, emulsions, suspensions and the like. The blumea balsamifera lipidosome disclosed by the invention has a good transdermal absorption effect and anti-inflammatory, analgesic and skin repairactivity effects, and is non-toxic and non-irritant to skin and mucous membranes.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a kind of ainasami oil liposome. Background technique [0002] Ainaxiang is a perennial woody herb of the genus Ainaxiang in the family Asteraceae, also known as Dafengai and Borneolum, and its medicinal parts are fresh or dried aerial parts. It has a long history of being used as a traditional national medicine in southern my country, and has the effects of analgesia, blood circulation, bruise treatment, body shaping and deodorization. Aina sesame oil is the essential oil refined from the leaves of the aerial part of Aina incense. It contains dozens of active ingredients, such as L-borneol, β-caryophyllene, camphor, γ-eucalyptol, 1-octene-3- alcohol, trans-ocimene, 1,3,4,5,6,7-hexahydro-2,5,5-trimethyl-2,4α-methylene and α-pinene, limonol and linalool acetate Compounds such as borneol esters. Pharmacological tests show that Aina sesame oil has good biological activities, such as antib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/127A61K47/28A61K47/24A61P29/00A61P31/04A61P31/12A61P17/00A61P7/04A61P17/04A61P17/02A61P1/02A61P11/02A61P15/02A61K8/92A61K8/14A61Q15/00A61Q5/00A61Q11/00
CPCA61K36/28A61K9/127A61K47/28A61K47/24A61P29/00A61P31/04A61P31/12A61P17/00A61P7/04A61P17/04A61P17/02A61P1/02A61P11/02A61P15/02A61K8/922A61K8/14A61Q15/00A61Q5/00A61Q11/00
Inventor 康冀川陈宝雯钱一鑫黄昌平王鲁方隐逸文丽
Owner GUIZHOU UNIV
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