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Method for producing disodium uridine-5'-monophosphate by a continuous flow reaction device

A disodium uridylate and reaction device technology, which is applied in the field of disodium uridylate production in a continuous flow reaction device, can solve the problems of low synthesis efficiency and yield, and achieve good mass transfer effect

Pending Publication Date: 2020-04-10
美亚药业海安有限公司
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Problems solved by technology

[0004] At present, the methods for preparing disodium uridine mainly include enzymatic hydrolysis and chemical synthesis, and some of them have relatively low synthesis efficiency and yield.

Method used

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  • Method for producing disodium uridine-5'-monophosphate by a continuous flow reaction device

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Embodiment Construction

[0017] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0018] see figure 1 , the present invention provides a technical solution: a method for producing disodium uridine in a continuous flow reaction device, comprising the following steps:

[0019] A. Prepare the mixed solution: pump the volume of the paper cup mixed solution into the mixer at the same time, and after mixing evenly, pump it into the mixed solution storage tank to obtain the mixed solution;

[0020] B. Paper cup uridine acid reaction solution: mix...

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Abstract

The invention discloses a method for producing disodium uridine-5'-monophosphate by a continuous flow reaction device. The method includes the following steps: A, preparing a mixed solution by simultaneously pumping solutions for preparing the mixed solution into a mixer, performing uniform mixing, pumping the mixed solution into a mixed solution storage tank to obtain the mixed solution; B, preparing a uridylic acid reaction solution by mixing a matched reagent and the mixed solution to prepare the uridylic acid reaction solution; and C, preparing the disodium uridine-5'-monophosphate: performing salt formation on the uridylic acid reaction solution, performing crystallization, performing filtration, and performing drying to obtain the disodium uridine-5'-monophosphate. In the preparationmethod for the disodium uridine-5'-monophosphate provided by the invention, the reaction time is shorter, in the reaction process, the mass transfer effect of a microchannel reactor is good, so thatthe selectivity and yield of the reactor are better than those of a previous preparation method, and the yield of the uridylic acid is about 97%.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a method for producing disodium uridine with a continuous flow reaction device. Background technique [0002] Disodium uridine can be used as an important intermediate in the production of nucleic acid drugs, health food and biochemical reagents. It is also used in the manufacture of uridine triphosphate, polyadenylic acid and other drugs, and plays an important role in the treatment of many major diseases. [0003] At present, with the expansion of the application range of uridine triphosphate, diuridine tetraphosphate, and uridine phosphatase inhibitors in the field of medicine, and the application of uridine diphosphate glucose pyrophosphorylase gene, domestic and foreign scientific research institutions and Enterprises have also increased the research and development of disodium uridine acid. [0004] At present, the methods for preparing disodium uridine mainly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H19/10C07H1/00B01J19/00
CPCB01J19/0093C07H1/00C07H19/10
Inventor 王宏苏浩傅得响
Owner 美亚药业海安有限公司
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