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Methods of boosting immune responses

A technology of immune response and immunogenicity, applied in the direction of vaccines, multivalent vaccines, pharmaceutical formulations, etc., can solve the problem that the method is not completely effective

Inactive Publication Date: 2020-04-10
GLAXOSMITHKLINE BIOLOGICALS SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even when targeted and optimally used, these approaches may not be fully effective

Method used

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  • Methods of boosting immune responses
  • Methods of boosting immune responses
  • Methods of boosting immune responses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0115] Embodiment 1. An immunogenic composition comprising (i) protein D (PD) or a fragment thereof from Haemophilus influenzae, (ii) protein E (PE) or a fragment thereof from Haemophilus influenzae, (iii) pilus protein A (PilA) or a fragment thereof from Haemophilus influenzae, and (iv) ubiquitin surface protein A2 (UspA2) or a fragment thereof from Moraxella catarrhalis for boosting a subject In a method against a pre-existing immune response to non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat), wherein the pre-existing immune response has been elicited by prior administration of at least two doses of a vaccine comprising PD , PE, PilA and UspA2, the method comprising the step of administering to the subject an immunogenic composition in an amount sufficient to elicit an immune response against PD, PE, PilA and UspA2 in the subject , in particular said immunogenic composition in an amount sufficient to elicit a further or additional immune response ...

Embodiment approach 2

[0116] Embodiment 2. The immunogenic composition for use in embodiment 1, wherein said subject has a previous history of chronic obstructive pulmonary disease (COPD).

Embodiment approach 3

[0117] Embodiment 3. The immunogenic composition for use in embodiment 2, wherein the subject has a prior history of moderate and severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD).

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Abstract

The present invention relates to immunogenic compositions, such as vaccines, comprising immunogenic polypeptides from Haemophilus influenzae and Moraxella catarrhalis, for use in methodsof boosting animmune response and methods of treatment using same. More particularly, the invention relates to use of such immunogenic compositions in methods of treating or preventing exacerbation of chronic obstructive pulmonary disease.

Description

[0001] field of invention [0002] The present invention relates to comprising from Haemophilus influenzae ( Haemophilus influenzae ) and Moraxella catarrhalis ( Moraxella catarrhalis ) immunogenic compositions, such as vaccines, for use in methods of boosting an immune response and methods of treatment using the same. More specifically, the present invention relates to the use of such immunogenic compositions in methods of treating or preventing exacerbations of chronic obstructive pulmonary disease. [0003] Background of the invention [0004] Chronic obstructive pulmonary disease (COPD), a common preventable disease, is characterized by persistent airflow limitation that is often progressive. Airflow limitation is associated with increased chronic inflammatory responses to noxious gas particles in the airways and lungs. The most important environmental risk factor for COPD is smoking, although other factors, such as occupational exposures, can also contribute to the dev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/102A61K39/104
CPCA61K39/102A61K39/1045A61K2039/55555A61K2039/55572A61K2039/55577A61K2039/70A61K2039/541A61K2039/545A61P31/04
Inventor A.K.阿罗拉V.韦南茨
Owner GLAXOSMITHKLINE BIOLOGICALS SA