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Application of AMPK (Adenosine 5'-monophosphate-activated protein kinase) agonist A769662 in preparing medicine for treating porcine reproductive and respiratory syndromes

An agonist, pig breeding technology, applied in the field of medical applications, can solve the problem of no anti-PRRSV virus drugs, etc., achieve good PRRSV replication, reduce morbidity and mortality, and reduce clinical symptoms

Inactive Publication Date: 2020-04-28
INST OF ANIMAL HUSBANDRY & VETERINARY MEDICINE HENAN ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the defects and problems that current vaccines cannot produce effective immune protection against PRRSV, and there are no good anti-PRRSV virus drugs, the present invention finds that AMPK agonist A769662 has the effect of anti-PRRSV virus replication, and provides an AMPK agonist New application of A769662 in the preparation of medicines for treating porcine reproductive and respiratory syndrome

Method used

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  • Application of AMPK (Adenosine 5'-monophosphate-activated protein kinase) agonist A769662 in preparing medicine for treating porcine reproductive and respiratory syndromes
  • Application of AMPK (Adenosine 5'-monophosphate-activated protein kinase) agonist A769662 in preparing medicine for treating porcine reproductive and respiratory syndromes
  • Application of AMPK (Adenosine 5'-monophosphate-activated protein kinase) agonist A769662 in preparing medicine for treating porcine reproductive and respiratory syndromes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: This example provides the application of AMPK agonist A769662, which is mainly used to prepare a drug containing AMPK agonist A769662 for the treatment of porcine reproductive and respiratory syndrome. The drug is an oral liquid, and the AMPK agonist A769662 is dissolved in Brown sugar, glucose or other pharmaceutically acceptable auxiliary materials are added to sterile water to prepare an oral liquid, and each kilogram of the oral liquid contains 5-8 mg of AMPK agonist A769662.

[0019] How to use: Mix oral liquid: drinking water at a ratio of 1:1000, and give it to pigs.

Embodiment 2

[0020] Example 2: This example provides a powder containing AMPK agonist A769662 for the treatment of porcine reproductive and respiratory syndrome. The AMPK agonist A769662 is added with auxiliary materials (starch, dextrin, etc.) according to a conventional method to make a powder. Contains 5-8 mg of the AMPK agonist A769662.

[0021] How to use: Mix well according to the ratio of powder:feed of 1:1000, and feed to pigs.

Embodiment 3

[0022] Embodiment 3: This embodiment provides a kind of aseptic powder of AMPK agonist A769662 as the original drug, which is dissolved and diluted with 1-2.5ml of sterile water for injection or sterile saline to make an injection, and each injection contains 0.01-0.025 mg of AMPK agonist A769662.

[0023] Method of use: intraperitoneal injection, one tablet per day.

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Abstract

The invention belongs to the field of medicine application and in particular relates to application of an AMPK (Adenosine 5'-monophosphate-activated protein kinase) agonist A769662 in preparing a medicine for treating porcine reproductive and respiratory syndromes. The invention finds that the AMPK agonist A769662 is capable of effectively inhibiting duplication of viruses of the porcine reproductive and respiratory syndromes, capable of remarkably alleviating clinical symptoms, reducing morbidity and mortality and reducing viral loads of pig tissue, and makes a basis for later research and development of medicines for treating the porcine reproductive and respiratory syndromes.

Description

technical field [0001] The invention belongs to the field of medical applications, in particular to the application of AMPK agonist A769662 in the preparation of medicines for treating porcine reproductive and respiratory syndrome. Background technique [0002] Porcine reproductive and respiratory syndrome (Porcine reproductive and respiratory syndrome, PRRS) is a contagious disease caused by porcine reproductive and respiratory syndrome virus (PRRSV). Arterivirus genus of the family Rhinoviridae. The full length of the genome is 15.4 kb, including 10 open reading frames (ORFs). PRRSV mainly infects porcine alveolar macrophages in pigs. The main clinical symptoms are late pregnancy abortion, stillbirth, weak fetus, mummified fetus, etc. in pregnant sows. It can also cause respiratory symptoms, disease Pig mortality increased. At present, the disease has become one of the important diseases that endanger the pig industry in the world, and it has also brought great economic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4365A61P31/14
CPCA61K31/4365A61P31/14
Inventor 方剑玉李海利郭小参王克领郎利敏朱文豪许峰王治方张青娴张立宪
Owner INST OF ANIMAL HUSBANDRY & VETERINARY MEDICINE HENAN ACAD OF AGRI SCI
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