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Protein hydrogel with gradient structure and preparation method thereof

A gradient structure and protein technology, applied in the field of polymer hydrogel, can solve complex problems and achieve the effects of low cost, good biocompatibility and biodegradability

Active Publication Date: 2020-04-28
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, current methods for preparing gradient materials are complex, require highly specialized equipment or special material properties (such as photosensitivity and magnetism), and are often limited by certain material parameters, such as viscosity or gel kinetic parameters.
A simple and convenient method for constructing protein hydrogels with gradient structures has not yet been found

Method used

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  • Protein hydrogel with gradient structure and preparation method thereof
  • Protein hydrogel with gradient structure and preparation method thereof
  • Protein hydrogel with gradient structure and preparation method thereof

Examples

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Effect test

Embodiment 1

[0021] A gradient structure protein hydrogel and a preparation method thereof, comprising the steps of:

[0022] (1) Preparation of solution: Weigh 15 g whey protein isolate and dissolve it in 85 g deionized water, stir at room temperature for 2 h until completely dissolved, prepare a whey protein isolate solution with a mass fraction of 15%, put in Refrigerate at 4°C for later use. Weigh 4 g of dodecyltrimethylammonium bromide and dissolve it in 100 mL of deionized water to prepare a dodecyltrimethylammonium bromide solution with a concentration of 0.04 g / mL.

[0023] (2) Preparation of protein hydrogel: adjust the pH of the whey protein isolate solution to 11 with 2 M sodium hydroxide solution, ultrasonically remove air bubbles in an ultrasonic cleaner for 30-60 s, and then pack them into cylindrical molds. Seal it, heat it in a water bath at 50 °C for 20 min, and then cool it to room temperature to obtain a protein hydrogel, which is stored in a refrigerator at 4 °C until ...

Embodiment 2

[0030] A gradient structure protein hydrogel and a preparation method thereof, comprising the steps of:

[0031] (1) Preparation of the solution: Weigh 15 g ovalbumin and dissolve it in 85 g deionized water, stir at room temperature for 2 h until completely dissolved, prepare ovalbumin solution with a mass fraction of 15 %, and put it in 4 °C Chill in the refrigerator until ready to use. Weigh 4 g of dodecyltrimethylammonium bromide and dissolve it in 100 mL of deionized water to prepare a dodecyltrimethylammonium bromide solution with a concentration of 0.04 g / mL.

[0032] (2) Preparation of protein hydrogel: adjust the pH of the ovalbumin solution to 11 with 2 M sodium hydroxide solution, ultrasonically remove air bubbles in an ultrasonic cleaner for 30-60 s, then divide into cylindrical molds, seal , heated in a water bath at 50°C for 20min, and then cooled to room temperature to obtain a protein hydrogel, which was then stored in a refrigerator at 4°C for later use.

[0...

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Abstract

The invention discloses protein hydrogel with a gradient structure and a preparation method thereof, wherein the protein hydrogel with the gradient structure is obtained by soaking preformed protein hydrogel in a surfactant solution. The protein hydrogel with the gradient structure prepared by the invention has a compact shell structure and a loose core structure, and the gradient structure of thehydrogel can be maintained after surfactant molecules are eluted. The method is simple, convenient and low in cost, the main components of the obtained gradient hydrogel have good biocompatibility and biodegradability, so that non-uniform porosity, mechanics, permeation and other properties can be provided, and the gradient hydrogel can be applied to the fields of biological materials, medical engineering and the like.

Description

technical field [0001] The invention belongs to the technical field of polymer hydrogel, and in particular relates to a protein hydrogel with a gradient structure and a preparation method thereof. Background technique [0002] Hydrogel is a kind of three-dimensional network structure material rich in water (>80%) formed by the cross-linking of polymer or colloidal particles. Hydrogels have unique physical and chemical properties, such as soft texture, rich in water, controllable mechanical properties, rapid medium conduction, and good biocompatibility, and have broad application prospects in tissue engineering, drug delivery, and other fields. [0003] As a natural amphoteric polymer, gelatinity is one of its most important functional properties. It can be used as an emulsifier, thickener and gelling agent in the food industry. Because of its good biocompatibility and biodegradability, it is widely used in the field of biomedicine. Surfactant is an amphiphilic molecule,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L89/00C08K5/19
CPCC08J3/075C08J2389/00C08K5/19
Inventor 黄彦汪少芸林珺琰林滋祺
Owner FUZHOU UNIV
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