Method and system for regulating and controlling number of ions in ion trap mass analyzer of mass spectrometer

Abstract

The invention discloses a method and system for regulating and controlling the number of ions in an ion trap mass analyzer of a mass spectrometer. The method comprises the steps of presetting the opening duration of a discontinuous sample injection interface, and introducing ions of a to-be-detected sample into an ion trap; carrying out initial mass spectrum analysis on the ions of the to-be-detected sample, storing and analyzing various initial parameters, and outputting initial mass spectrum information; analyzing the number of ions which enter the ion trap and are stored, and changing eachinitial parameter to regulate and control the number of ions; establishing a relation model between each initial parameter and the number of ions through a pre-experiment, carrying out gain compensation on the spectral peak intensity obtained after regulation and control, and determining each optimal initial parameter; and carrying out mass spectrometric analysis by using the optimal initial parameters, and outputting a mass spectrogram of which the spectral peak intensity corresponds to the sample concentration. According to the method, the dynamic range of the concentration of the sample which can be detected by the portable mass spectrometer can be greatly improved, meanwhile, the sensitivity, the resolution ratio, the quality accuracy and other properties are also remarkably improved,and the capacity of the portable mass spectrometer for treating complex samples is also enhanced.

Description

technical field [0001] The invention relates to the technical field of mass spectrometry, in particular to a method and system for regulating the number of ions in an ion trap mass analyzer of a mass spectrometer. Background technique [0002] The ion trap mass analyzer is a device that uses an electric field to capture and trap ions within a certain range. Because of its small size and low requirements for vacuum, it is widely used in small mass spectrometers. However, if there are too many ions trapped in the ion trap, there will be a space charge effect, that is, the Coulomb repulsion between the ions will cause the "mass shift" phenomenon of the ions, so that the peak intensity in the mass spectrum cannot reflect the true concentration of the ions , and the resolution of the instrument is reduced, and the mass accuracy is reduced. To avoid this phenomenon, various methods are used to control the amount of ions entering the ion trap mass analyzer. [0003] However, the ...

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Problems solved by technology

[0005] In addition, ease of operation is an important feature of portable mass spectrometers, but its target group is on-site workers who do not have professional operating skills and corresponding analytical chemistry knowledge background. Overly complicated adjustment methods will greatly affect the application of portable mass spectrometers

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