Method and system for regulating the number of ions in an ion trap mass analyzer of a mass spectrometer

Abstract

The invention discloses a method and a system for regulating the number of ions in an ion trap mass analyzer of a mass spectrometer, wherein the method comprises: presetting the opening time of a discontinuous sample injection interface, introducing sample ions to be tested into the ion trap; Perform initial mass spectrometry analysis on sample ions, save and analyze various initial parameters, and output initial mass spectrum information; analyze the number of ions entering and stored in the ion trap, and change various initial parameters to control the number of ions; establish various initial parameters through pre-experiments The relationship model between the parameters and the number of ions, and the gain compensation is performed on the intensity of the spectral peaks obtained after adjustment, and the optimal initial parameters are determined; the optimal initial parameters are used for mass spectrometry analysis, and the mass spectrum corresponding to the intensity of the spectral peaks and the sample concentration is output. . This method can greatly improve the dynamic range of the sample concentration detectable by the portable mass spectrometer, and at the same time, the performance such as sensitivity, resolution, and mass accuracy can also be significantly improved, and its ability to handle complex samples is also enhanced.

Description

technical field [0001] The invention relates to the technical field of mass spectrometry, in particular to a method and system for regulating the number of ions in an ion trap mass analyzer of a mass spectrometer. Background technique [0002] The ion trap mass analyzer is a device that uses an electric field to capture and trap ions within a certain range. Because of its small size and low requirements for vacuum, it is widely used in small mass spectrometers. However, if there are too many ions trapped in the ion trap, there will be a space charge effect, that is, the Coulomb repulsion between the ions will cause the "mass shift" phenomenon of the ions, so that the peak intensity in the mass spectrum cannot reflect the true concentration of the ions , and the resolution of the instrument is reduced, and the mass accuracy is reduced. To avoid this phenomenon, various methods are used to control the amount of ions entering the ion trap mass analyzer. [0003] However, the ...

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Problems solved by technology

[0005] In addition, ease of operation is an important feature of portable mass spectrometers, but its target group is on-site workers who do not have professional operating skills and corresponding analytical chemistry knowledge background. Overly complicated adjustment methods will greatly affect the application of portable mass spectrometers

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