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Traditional Chinese medicine composition for improving quality and quantity of egg cells as well as preparation method and application of composition

A composition and egg cell technology, applied in the field of traditional Chinese medicine, can solve the problems of less side effects

Inactive Publication Date: 2020-06-09
百创汇国际生物科技(武汉)股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far there is no drug that targets the decline in egg quality and quantity caused by DOR, has a clear scope of application, and has few side effects

Method used

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  • Traditional Chinese medicine composition for improving quality and quantity of egg cells as well as preparation method and application of composition
  • Traditional Chinese medicine composition for improving quality and quantity of egg cells as well as preparation method and application of composition
  • Traditional Chinese medicine composition for improving quality and quantity of egg cells as well as preparation method and application of composition

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Experimental program
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Effect test

Embodiment 1

[0032] A traditional Chinese medicine composition for improving the quality and quantity of egg cells. Seed medicines such as medlar, privet lucidum, schisandra, mulberry, and silkworm are used as the king, and the shape is replenished, and the essence is nourished; supplemented with rehmannia glutinosa and sealwort , white peony root, angelica, etc. to nourish yin and blood, clear deficiency and heat, to strengthen nourishing yin and blood, nourish essence and replenish essence as ministers; with Chinese yam, jujube, tangerine peel and other drugs to strengthen the spleen, replenish qi and promote qi; epimedium, Cuscuta, etc. use yang to seek yin; Danshen, Spatholobus, Yunling, Plantago, etc. are used to invigorate blood and nourish blood, invigorate the spleen and expel dampness. The whole formula improves the internal environment of the whole body including the pelvic cavity, adjusts the functions of the ovaries and the ovarian axis, bases itself on enriching sperm and raisi...

Embodiment 2

[0045] Clinical Observation and Screening

[0046] The medicine of the present invention is based on the theory of traditional Chinese medicine, aiming at the special physiological stage of "kidney essence deficiency" of women, on the basis of clinical experience, with the help of modern Chinese medicine pharmacology theory, after long-term clinical application research. The inventor has obtained a traditional Chinese medicine compound aimed at improving the quality and quantity of eggs through repeated clinical observation and screening for more than 20 years. The clinical observation method is through the retrospective analysis of the patients' own before and after comparison. The subjects included in the study were all test-tube baby transplantation (IVF) patients who took Liu's Yuqi Fang and had observation data before and after treatment. The results showed that: Liu's Yu egg formula is effective in increasing the number of antral follicles (AFC), third-day embryos, blas...

Embodiment 3

[0058] Clinical Trials

[0059] (1) General condition of the patient: Wu, female, 38 years old, married for 10 years but not pregnant, with normal menstrual flow. Such as Image 6 with 7 As shown, the FSH level of the patient before treatment was 11mIU / ml, the basal follicle count of bilateral ovaries was only 3, and the AMH level was 0.78ng / ml, which was significantly lower than the average level of his age group. Diagnosis: diminished ovarian reserve.

[0060] (2) After treatment

[0061] Such as Image 6 with 7 Shown, the patient takes this medicine granule, once a day, each 4 grams. After only one month, the FSH level dropped to 9.7mIU / ml. Continue to take this medicine (same dose), after three months, the basic follicle count of bilateral ovaries increases to 9, and AMH increases to 2.2ng / ml.

[0062] The patient then received a mini-stimulation cycle test-tube baby (Mini-IVF) treatment. The ovulation promotion plan was GONAL-f 200 units for ten days, five eggs we...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for improving the quality and quantity of egg cells as well as a preparation method and application of the composition. The traditional Chinese medicine composition provided by the present application is based on the classic Chinese medicine prescription ''Wuzi Yanzong Pill'', and mainly uses seed medicines such as fructus lycii, fructus ligustri lucidi, fructus schisandrae chinensis, mulberry seed and dodder seed for the physiological and pathological characteristics of yin essence loss of middle-aged women to supplement a form by a form and nourish the essence and replenish the essence; rehmannia root, rhizoma polygonati, radix paeoniae alba and radix angelicae sinensis for nourishing yin blood and clearing deficiency heat to strengthen nourishing of yin and blood and nourishing and replenishing of the essence are used as adjuvant medicines; the medicines such as rhizoma dioscoreae from Henan of China, Chinese date and dried tangerine peel are used to strengthen the spleen and supplement qi and promote qi; and herba epimedii and thedodder seed are used to seek yin in yang; danshen root, caulis spatholobi, poria cocos and semen plantaginis are used to activate blood circulation and nourish blood, strengthen spleen and clear dampness. The whole prescription improves the quality and quantity of ova by improving the internal environment of the whole body including a pelvic cavity, and adjusting the functions of an ovary and ovarian axis based on the purpose of replenishing essence and nourishing ova to treat symptoms from root causes.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for improving the quality and quantity of egg cells, a preparation method and application thereof. Background technique [0002] Ovarian reserve function reflects the ability of follicles to grow and develop in the ovarian cortex to form fertilizable oocytes, refers to the quantity and quality of follicles remaining in the ovary, reflects the fertility potential, and is an important symbol of female fertility. Diminished ovarian reserve (DOR) refers to the reduction in the number and / or quality of oocytes in the ovary, accompanied by a decrease in the level of anti-Müllerian hormone (AMH) and the number of antral follicles. (antral follicle count, AFC) decreased and FSH level increased. Patients are less fertile, but age, etiology, and menstrual status are not emphasized. The level of ovarian reserve fu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/16A61P15/08
CPCA61K9/1652A61K36/076A61K36/232A61K36/296A61K36/39A61K36/43A61K36/486A61K36/537A61K36/57A61K36/605A61K36/638A61K36/65A61K36/68A61K36/71A61K36/725A61K36/752A61K36/79A61K36/804A61K36/815A61K36/8945A61K36/8969A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P15/08A61K2300/00
Inventor 刘小玉
Owner 百创汇国际生物科技(武汉)股份有限公司
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