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Resveratrol water-soluble composition as well as preparation method and application thereof

A technology of resveratrol and composition, applied in the field of resveratrol water-soluble composition and preparation thereof, can solve problems such as rare preparations, complex traditional Chinese medicine ingredients, etc., achieve good therapeutic effect, treat hyperlipidemia, Simple preparation method

Inactive Publication Date: 2020-06-12
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies in recent years have shown that some traditional Chinese medicines have been used to prevent and treat arteriosclerosis. However, due to the complexity of the theory of traditional Chinese medicine and the complexity of the ingredients of traditional Chinese medicine, it is clinically used to treat arteriosclerosis with good bioavailability and good results. Preparations are rare

Method used

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  • Resveratrol water-soluble composition as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: Chinese medicine composition containing resveratrol

[0024] Raw materials: made of the following raw materials in parts by weight: 40 parts of Polygonum cuspidatum, 20 parts of Zezhu and 20 parts of Ginkgo biloba; the preparation method includes the following steps: S1: weighing Curcuma according to the above weight ratio, drying, crushing and passing through an 80-mesh sieve, Place in a supercritical extraction kettle, add 95v / v% ethanol as entrainer, set CO 2 The flow rate is 20ml / min, the extraction pressure is 30MPa, the extraction temperature is 40-50°C, and the extraction time is 2h. 2 The supercritical extract was obtained by extraction, and the entrainer ethanol was recovered by a rotary evaporator to obtain the extract 1 and medicinal residues; S2: weigh the knotweed and ginkgo leaves according to the above weight ratio, mix them uniformly, dry and crush them into 300 meshes, Mix with the dregs obtained in step S1, add 10 times the mass of 90v / v...

Embodiment 2

[0025] Embodiment 2: Chinese medicine composition containing resveratrol

[0026] Raw materials: made from the following raw materials in parts by weight: 80 parts of knotweed, 40 parts of curcuma and 40 parts of ginkgo leaves; the preparation method includes the following steps:

[0027] S1: Weigh Curcuma Curcuma according to the above weight ratio, dry it, crush it and pass through a 40-mesh sieve, put it in a supercritical extraction kettle, add 95v / v% ethanol as an entrainer, and set CO 2 The flow rate is 10ml / min, the extraction pressure is 20MPa, the extraction temperature is 40°C, and the extraction time is 1h. 2The supercritical extract is obtained by extraction, and the entrainer ethanol is recovered by a rotary evaporator to obtain extract 1 and medicinal residues; S2: Weigh Polygonum cuspidatum and Ginkgo biloba according to the above weight ratio, mix them uniformly, dry and crush them into 100 meshes, Mix it with the dregs obtained in step S1, add 6 times the mas...

Embodiment 3

[0028] Embodiment 3: Chinese medicine composition containing resveratrol

[0029] Raw materials: made from the following raw materials in parts by weight: 60 parts of knotweed, 30 parts of curcuma and 30 parts of ginkgo leaves; the preparation method includes the following steps:

[0030] S1: Weigh Curcuma Curcuma according to the above weight ratio, dry it, crush it and pass through a 60-mesh sieve, put it in a supercritical extraction kettle, add 95v / v% ethanol as an entrainer, and set CO 2 The flow rate is 16ml / min, the extraction pressure is 24MPa, the extraction temperature is 45°C, and the extraction time is 1.5h. 2 The supercritical extract is obtained by extraction, and the entrainer ethanol is recovered by a rotary evaporator to obtain the extract 1 and medicinal residues; S2: weigh the Polygonum cuspidatum and Ginkgo biloba according to the above weight ratio, mix them uniformly, dry and crush them into 200 meshes, Mix with the dregs obtained in step S1, add 8 times...

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Abstract

The invention discloses a resveratrol water-soluble composition which is characterized by comprising a resveratrol-containing traditional Chinese medicine composition and a pharmaceutically acceptablecarrier, and the mass ratio of the resveratrol-containing traditional Chinese medicine composition to the pharmaceutically acceptable carrier is 1: (5-20). The traditional Chinese medicine composition containing resveratrol is prepared from the following raw materials in parts by weight: 40-80 parts of polygonum cuspidatum, 20-40 parts of curcuma zedoary and 20-40 parts of ginkgo leaves. The traditional Chinese medicine components are matched for use; and are combined to provide effects of blood fat reducing and effective treatment of hyperlipidemia and arteriosclerosis, and the traditional Chinese medicine compound preparationn is prepared into the solid dispersion, such that the preparation method is simple, the water-soluble resveratrol composition is obtained, the bioavailability of the pharmaceutical composition is significantly improved, and the good treatment effect is provided.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a resveratrol water-soluble composition and a preparation method and application thereof. Background technique [0002] Lipids contained in blood plasma are collectively referred to as blood lipids, which is a general term for triglycerides and lipids (phospholipids, glycolipids, cholesterol, steroids) in plasma, which are widely present in the human body. They are essential substances for the basic metabolism of living cells. Generally speaking, the main components of blood lipids are triglycerides and cholesterol, of which triglycerides participate in energy metabolism in the human body, while cholesterol is mainly used for the synthesis of cell membranes, steroid hormones and bile acids. All blood lipids combine with proteins to form lipoproteins. The basic structure of lipoprotein is a core of triglycerides with different contents, surrounded by a layer of phos...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K31/05A61K47/10A61K47/32A61K47/44A61P3/06A61P9/10
CPCA61K31/05A61K36/704A61K36/9066A61K36/16A61K47/10A61K47/32A61K47/44A61P3/06A61P9/10A61K2236/37A61K2236/333A61K2236/55A61K2236/39A61K2300/00
Inventor 王霞任屹清
Owner QINGDAO UNIV OF SCI & TECH
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