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Medicine for treating early severe acute pancreatitis

A technology of acute pancreatitis and drugs, applied in the field of drugs for the treatment of severe acute pancreatitis in the early stage, can solve the problems of untreated acute pancreatitis, protect gastrointestinal cells, inhibit inflammation, inhibit endotoxin translocation and bacterial translocation Effect

Inactive Publication Date: 2020-07-17
青海省人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, the combination of traditional Chinese and western medicine has achieved remarkable effects in relieving the clinical symptoms of patients with SAP, improving the clinical cure rate, reducing the incidence of complications and mortality. At present, the combination of traditional Chinese and western medicine has become an important measure to treat SAP, but there is no The Ideal Drug of Traditional Chinese Medicine for Treating Acute Pancreatitis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A medicine for treating severe acute pancreatitis at an early stage, prepared through the following steps:

[0023] S1. Weighing by weight: 10 parts of rhubarb, 5 parts of baicalin, 10 parts of calamus, 5 parts of andrographolide, 10 parts of dipixiao, 5 parts of Zhuru, 10 parts of citrus aurantium, 5 parts of L-glutamine, 10 parts of raw gardenia, 5 parts of gerbera, 5 parts of spider incense, 5 parts of red;

[0024] S2. Wash the weighed rhubarb, scutellaria, calamus, andrographolide, dipixiao, zhuru, citrus aurantium, raw gardenia, gerbera, spider incense, and a little red, slice / segment, and place in- Under the condition of 15°C, after freezing and embrittlement for 1 hour, under the condition of 25-30°C, ultrasonic wall breaking treatment is carried out to obtain the broken Chinese herbal medicine powder;

[0025] S2. Put the Chinese herbal medicine powder in the enzymolysis tank, add cellulase in a proportion of 2-3% by mass, add glucose isomerase in a proportion...

Embodiment 2

[0028] A medicine for treating severe acute pancreatitis at an early stage, prepared through the following steps:

[0029] S1. Weighing by weight: 20 parts of rhubarb, 10 parts of baicalin, 15 parts of calamus, 10 parts of andrographolide, 20 parts of dipixiao, 10 parts of Zhuru, 20 parts of citrus aurantium, 10 parts of L-glutamine, 20 parts of raw gardenia, 15 parts of gerbera, 15 parts of spider incense, 15 parts of red;

[0030] S2. Wash the weighed rhubarb, scutellaria, calamus, andrographolide, dipixiao, zhuru, citrus aurantium, raw gardenia, gerbera, spider incense, and a little red, slice / segment, and place in- Under the condition of 15°C, after freezing and embrittlement for 1 hour, under the condition of 25-30°C, ultrasonic wall breaking treatment is carried out to obtain the broken Chinese herbal medicine powder;

[0031] S2. Put the Chinese herbal medicine powder in the enzymolysis tank, add cellulase in a proportion of 2-3% by mass, add glucose isomerase in a pro...

Embodiment 3

[0034] A medicine for treating severe acute pancreatitis at an early stage, prepared through the following steps:

[0035] S1, weighed by weight: 15 parts of rhubarb, 7.5 parts of baicalin, 12.5 parts of calamus, 7.5 parts of andrographolide, 15 parts of dipixiao, 7.5 parts of Zhuru, 15 parts of citrus aurantium, 7.5 parts of L-glutamine, 15 parts of raw gardenia, 10 parts of gerbera, 10 parts of spider incense, 10 parts of red;

[0036] S2. Wash the weighed rhubarb, scutellaria, calamus, andrographolide, dipixiao, zhuru, citrus aurantium, raw gardenia, gerbera, spider incense, and a little red, slice / segment, and place in- Under the condition of 15°C, after freezing and embrittlement for 1 hour, under the condition of 25-30°C, ultrasonic wall breaking treatment is carried out to obtain the broken Chinese herbal medicine powder;

[0037] S2. Put the Chinese herbal medicine powder in the enzymolysis tank, add cellulase in a proportion of 2-3% by mass, add glucose isomerase in ...

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Abstract

The invention discloses a medicine for treating early severe acute pancreatitis. The medicine is prepared from the following raw materials in parts by weight: 10-20 parts of radix et rhizoma rhei, 5-10 parts of radix scutellariae, 10-15 parts of rhizoma acori graminei, 5-10 parts of andrographolide, 10-20 parts of delavay pararuellia herb, 5-10 parts of caulis bambusae in taeniam, 10-20 parts of fructus aurantii immaturus, 5-10 parts of L-glutamine, 10-20 parts of unprocessed gardenia jasminoides, 5-15 parts of herba gerberae piloselloidis, 5-15 parts of jatamans valeriana rhizome and 5-15 parts of emilia Herb. According to the medicine, the formula of the medicine is safe and reliable, the components complement each other, the effects of clearing away heat and toxic materials, removing blood stasis and relieving pain, clearing the organs and relieving pancreas, strengthening the spleen and liver, protecting gastrointestinal cells and enhancing defense function of a body are achieved,the translocation of endotoxin and bacteria can be inhibited, and the inflammation is inhibited.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a medicine for treating severe acute pancreatitis in the early stage. Background technique [0002] Acute pancreatitis (AP) is one of the common acute abdominal diseases in clinical practice. It has the characteristics of acute onset, rapid disease progression, long treatment time, high cost, and high mortality rate. Once it occurs, it often requires immediate hospitalization. Accompanied by persistent (> 48h) organ failure and systemic inflammatory response syndrome (systemic inflammatory response syndrome, SIRS) is diagnosed as severe acute pancreatitis (severe acute pancreatitis, SAP). The fatality rate of SAP is relatively high, originally 36%-50%. In recent years, with the improvement of treatment methods, the mortality rate has dropped to 20-30%. According to the condition of SAP, it can be divided into early, middle and late stages, among which the early and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P1/18A61K31/365A61K31/198
CPCA61K31/198A61K31/365A61K36/19A61K36/28A61K36/539A61K36/708A61K36/744A61K36/752A61K36/84A61K36/888A61K36/899A61K2236/19A61P1/18A61K2300/00
Inventor 朱海宏杨效杨育文曹涛杨德武马福财
Owner 青海省人民医院
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