The preparation method of decyl oleate

A technology of decyl oleate and oleic acid, applied in the field of preparation of decyl oleate, can solve the problem that the stability of the new crown vaccine cannot be improved, the preparation method of decyl oleate is not found, the purity of decyl oleate is difficult to guarantee, etc. problems, to achieve the effect of inhibiting side reactions and reverse reactions, shortening reaction time, and improving product purity

Active Publication Date: 2022-04-15
广州隽沐生物科技股份有限公司
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  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, no preparation method of decyl oleate has been found at present, and the purity of decyl oleate purchased from the market is difficult to guarantee. If the purity of decyl oleate cannot reach more than 98%, it will not only fail to improve the quality of the new crown vaccine. The effect of the stability of the new crown vaccine may even have an impact on the efficacy of the new crown vaccine. Therefore, providing a preparation method of decyl oleate is of great significance for the further research of the new crown vaccine

Method used

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  • The preparation method of decyl oleate
  • The preparation method of decyl oleate
  • The preparation method of decyl oleate

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A preparation method for decyl oleate, comprising the following steps:

[0043] In step (1), add 1 kg of oleic acid and 1 kg of n-decyl alcohol into a four-neck flask, and mix evenly to form a premix.

[0044] Step (2), continue to add 0.22kg SO in the four-necked flask 4 2- / Fe 2 o 3 Solid superacid, mix well to form a mixture.

[0045]Step (3), the four-necked flask that mixture is housed is put into oil bath, and installs condensing pipe so that the water vapor in the reaction system is discharged at one of the openings of four-necked flask, while condensing pipe is away from four-necked flask Place an Erlenmeyer flask at one end to collect the water formed by the condensation of water vapor, and seal the other opening of the four-neck flask with a rubber stopper, then heat the oil bath to 160°C, react for 12 hours, and cool to room temperature to obtain decyl oleate ester.

[0046] see figure 1 , for the decyl oleate prepared in this example 1 HNMR spectrum,...

Embodiment 2

[0048] The difference from Example 1 is that the reaction temperature in step (3) is 280°C, and the reaction time is 5h.

Embodiment 3

[0050] The difference with Example 1 is: the reaction temperature in step (3) is 220°C, and the reaction time is 4h

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Abstract

The present invention relates to the technical field of compound synthesis. Aiming at the problem that there is no preparation method of decyl oleate in the prior art, a preparation method of decyl oleate is provided, which includes the following steps: step (1), mixed oil Acid and n-decyl alcohol form a premix; step (2), add catalyst to the premix to form a mixture; step (3), heat the mixture to 160°C-280°C, react for 2-12h, take the reacted mixture to obtain decyl oleate. The invention has the effects of accelerating the reaction rate, improving the yield of the reaction and the purity of the product.

Description

technical field [0001] The invention relates to the technical field of compound synthesis, in particular to a preparation method of decyl oleate. Background technique [0002] At present, from a biological point of view, decyl oleate is a substance similar to skin fat, and it is non-irritating. It is a light yellow transparent liquid at room temperature and can be miscible with most commonly used fat materials. . [0003] Decyl oleate has good fluidity, strong diffusivity, strong penetration and high temperature resistance. Through a large number of toxicity tests and skin tests, it has been confirmed that decyl oleate can adapt to human physiological conditions. [0004] According to the latest research, decyl oleate is expected to be used to prepare a stabilizer for the new crown vaccine to improve the stability of the new crown vaccine during storage, making the new crown vaccine less likely to lose its activity during storage, and thus making the new crown vaccine more ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/58C07C67/08
CPCC07C67/08C07C2527/054C07C2527/135C07C69/58
Inventor 邹小燕李小蕾周仁学易嘉辉徐楷区沛明黄凤尧林凯文黄娇王鹏
Owner 广州隽沐生物科技股份有限公司
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