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Drug-loaded particles, catheter with drug-loaded particles and implantation system

A technology of drug-loaded particles and catheters, applied in catheters, drug devices, medical science, etc., can solve the problems of reaching the lungs, failure, leakage, etc., and achieve the effects of improving production efficiency, changing manufacturing methods, and precise control

Pending Publication Date: 2020-07-24
MEDESSENCE LIFESCIENCES SUZHOU INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For tumor tissues that are not rich in blood supply, or after multiple interventional treatments, the tumor blood vessels are replaced by small and multi-branched collateral blood vessels, the delivery of microspheres through vascular access is limited or fails.
[0005] In addition, there are often various arteriovenous fistulas inside the tumor. At this time, the microspheres sent through the arterial route not only fail to stay in the tumor as designed to play a therapeutic role, but also leak into the vein through the fistula, and finally reach the lungs. department, with serious consequences

Method used

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  • Drug-loaded particles, catheter with drug-loaded particles and implantation system
  • Drug-loaded particles, catheter with drug-loaded particles and implantation system
  • Drug-loaded particles, catheter with drug-loaded particles and implantation system

Examples

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Embodiment Construction

[0034] The technical content of the present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0035] Such as Figure 1 ~ Figure 3 As shown, the drug-loaded particle 3 provided by the embodiment of the present invention includes a shell 31 and a drug-loaded part 34 accommodated inside the shell 31 . Wherein, the shell 31 is a biodegradable material, which may not be loaded with drug, or may be made of microsphere material or drug-loaded material, so as to realize drug loading on the shell. The length of the drug-loaded particles 3 is in the range of 2-8 mm, especially greater than 5 mm and less than 7 mm. Drug-loaded particles of this size can be fixed in a certain position after being implanted into tissues in the body to release drugs continuously.

[0036] Such as figure 2 with image 3 As shown, the housing 31 has a plurality of slots 33 having different depths. At the position of the slot 33 with a l...

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Abstract

The present invention discloses drug-loaded particles. The particles comprise a biodegradable housing (31), and a drug-loaded portion (34) arranged inside the housing and used for being implanted intoin-vivo tissues via a puncture needle (5), the drug-loaded portion (34) comprises a drug, and the housing is closed and designed to form an opening through a wall thickness of the housing at a predetermined time. The drug-loaded particles provided by the embodiment of the invention have a relatively large size, can be directly implanted into in-vivo tissues, and does not need to pass through a blood vessel. Moreover, drug-loaded particles containing different drugs can be implanted through one-time puncture and needle insertion, so that the different drugs are promoted mutually, and the curative effect is improved. According to the invention, different drug-loaded particles can have different drug release speed curves respectively, and a plurality of drug-loaded particles with different drug release speed curves can be implanted at one time, so that accurate control of drug release can be realized.

Description

technical field [0001] The invention relates to a drug-loaded particle (abbreviated as a particle), and also relates to a catheter and an implantation system with the drug-loaded particle, which belongs to the technical field of medical interventional devices. Background technique [0002] With the increasing popularity of interventional surgery, microsphere technology has been greatly developed. For example, Jialisheng, a subsidiary of Hengrui Medicine, has developed CalliSpheres drug-loaded embolic microspheres and 8Spheres conformal embolic microspheres. Drug-loaded microspheres can be divided into biodegradable (gelatin microspheres, degradable starch microspheres, sodium alginate microspheres) and non-biodegradable (with polyvinyl alcohol modified microspheres, polyvinyl alcohol, sodium acrylate copolymer Microspheres). [0003] Microsphere interventional surgery usually injects drug-loaded microspheres into venous blood vessels through a catheter, and the blood in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K51/12A61L27/54A61L27/58A61L27/50A61L29/14A61L29/16A61L29/18A61M37/00A61N5/10
CPCA61K9/0024A61K9/5031A61K51/1251A61L27/50A61L27/54A61L27/58A61L29/14A61L29/16A61L29/18A61L2300/622A61M37/0069A61N5/1027
Inventor 董永华何元
Owner MEDESSENCE LIFESCIENCES SUZHOU INC
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