Drug-loaded particles, catheter with drug-loaded particles and implantation system

Abstract

The present invention discloses drug-loaded particles. The particles comprise a biodegradable housing (31), and a drug-loaded portion (34) arranged inside the housing and used for being implanted intoin-vivo tissues via a puncture needle (5), the drug-loaded portion (34) comprises a drug, and the housing is closed and designed to form an opening through a wall thickness of the housing at a predetermined time. The drug-loaded particles provided by the embodiment of the invention have a relatively large size, can be directly implanted into in-vivo tissues, and does not need to pass through a blood vessel. Moreover, drug-loaded particles containing different drugs can be implanted through one-time puncture and needle insertion, so that the different drugs are promoted mutually, and the curative effect is improved. According to the invention, different drug-loaded particles can have different drug release speed curves respectively, and a plurality of drug-loaded particles with different drug release speed curves can be implanted at one time, so that accurate control of drug release can be realized.

Description

technical field [0001] The invention relates to a drug-loaded particle (abbreviated as a particle), and also relates to a catheter and an implantation system with the drug-loaded particle, which belongs to the technical field of medical interventional devices. Background technique [0002] With the increasing popularity of interventional surgery, microsphere technology has been greatly developed. For example, Jialisheng, a subsidiary of Hengrui Medicine, has developed CalliSpheres drug-loaded embolic microspheres and 8Spheres conformal embolic microspheres. Drug-loaded microspheres can be divided into biodegradable (gelatin microspheres, degradable starch microspheres, sodium alginate microspheres) and non-biodegradable (with polyvinyl alcohol modified microspheres, polyvinyl alcohol, sodium acrylate copolymer Microspheres). [0003] Microsphere interventional surgery usually injects drug-loaded microspheres into venous blood vessels through a catheter, and the blood in th...

AI Technical Summary

Problems solved by technology

For tumor tissues that are not rich in blood supply, or after multiple interventional treatments, the tumor blood vessels are replaced by small and multi-branched collateral blood vessels, the delivery of microspheres through vascular access is limited or fails.

[0005] In addition, there are often various arteriovenous fistulas inside the tumor. At this time, the microspheres sent through the arterial route not only fail to stay in the tumor as designed to play a therapeutic role, but also leak into the vein through the fistula, and finally reach the lungs. department, with serious consequences

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