Cefuroxime magnesium compound, composition, preparation method and use

A nitroxane magnesium compound and a technology for the magnesium compound, applied in the field of medicine, can solve the problems such as the stability of cefuroxime sodium needs to be improved, and achieve the effects of improved stability and simple operation

Active Publication Date: 2021-06-08
CHENGDE MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stability of cefuroxime sodium still needs to be improved

Method used

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  • Cefuroxime magnesium compound, composition, preparation method and use
  • Cefuroxime magnesium compound, composition, preparation method and use
  • Cefuroxime magnesium compound, composition, preparation method and use

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preparation example Construction

[0021] see figure 1 , figure 1 It is a schematic flow diagram of an embodiment of the preparation method of cefuroxime magnesium compound of the present invention, the method comprising:

[0022] Step S101: providing a compound containing cefuroxime and providing a magnesium compound.

[0023] Step S102: making a chemical reaction between the cefuroxime-containing compound and the magnesium compound.

[0024] Step S103: obtaining the product of the cefuroxime magnesium compound obtained by the chemical reaction.

[0025] Compounds containing cefuroxime include, but are not limited to: cefuroxime acid.

[0026] Magnesium compounds include, but are not limited to, magnesium hydroxide, magnesium bicarbonate, magnesium acetate, and the like.

[0027] Wherein, the molar ratio of cefuroxime to magnesium is 2:1.

[0028] In the preparation method of the embodiment of the present invention, the reaction product containing cefuroxime and the magnesium compound undergoes a chemical...

Embodiment 1

[0063] The preparation method of cefuroxime magnesium compound comprises the following steps:

[0064] (A) Preparation of cefuroxime acid suspension: sieve 0.02 mole of cefuroxime acid, add powdered cefuroxime acid to 80 ml of purified water and suspend to obtain cefuroxime acid suspension;

[0065] (B) Preparation of a magnesium compound suspension: crush 0.01 mole of magnesium bicarbonate into fine powder, sieve, add the powdered magnesium compound to 50 ml of purified water, and suspend to obtain a magnesium compound suspension;

[0066] (C) Reaction: adding the magnesium compound suspension obtained in step B into the cefuroxime suspension obtained in step A according to a certain proportion, stirring at a temperature of 25° C., adding activated carbon to stir for decolorization, and filtering to obtain a filtrate;

[0067] (D) drying: freeze-drying the filtrate obtained in step C to obtain the cefuroxime magnesium compound.

Embodiment 2

[0069] The preparation method of cefuroxime magnesium compound comprises the following steps:

[0070] (A) Preparation of cefuroxime suspension: 0.02 moles of cefuroxime was sieved, and powdered cefuroxime was added to 50 ml of purified water to obtain a cefuroxime suspension;

[0071] (B) Preparation of a magnesium compound suspension: crush 0.01 mole of magnesium acetate into fine powder, sieve, add the powdered magnesium compound to 20 ml of purified water and suspend to obtain a magnesium compound suspension;

[0072] (C) Reaction: adding the magnesium compound suspension obtained in step B into the cefuroxime suspension obtained in step A according to a certain proportion, stirring at a temperature of 30° C., adding activated carbon to stir for decolorization, and filtering to obtain a filtrate;

[0073] (D) drying: the filtrate obtained in step C is dried to obtain the cefuroxime magnesium compound.

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Abstract

The invention discloses a cefuroxime magnesium compound, composition, preparation method and application. The preparation method comprises: providing a cefuroxime-containing compound, providing a magnesium compound; making the cefuroxime-containing compound and the magnesium The compound is chemically reacted; the product of the chemically reacted cefuroxime magnesium compound is obtained. In this way, the present invention can provide technical support for realizing large-scale industrial production, and can improve the stability of cefuroxime salt.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a cefuroxime magnesium compound, a composition, an antibacterial composition, a preparation method and an application of the cefuroxime magnesium compound. Background technique [0002] Cefuroxime is a second-generation cephalosporin with broad-spectrum antibacterial activity and a wide range of applications. It can be used for respiratory tract infections, ear, nose, throat infections, urinary tract infections, skin and soft tissue infections, bone and Joint infections, gonorrhea, other infections including sepsis and meninges. [0003] The commonly used injection in clinic is cefuroxime sodium. Cefuroxime sodium is usually administered intravenously or intramuscularly. However, the stability of cefuroxime sodium still needs to be improved. Contents of the invention [0004] The technical problem mainly solved by the present invention is to provide a cefuroxime magnesium c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/34C07D501/04A61K31/546A61P31/04
CPCA61P31/04C07D501/34
Inventor 刘翠哲刘金霞宋鸿儒魏晓芬金鹏白红红
Owner CHENGDE MEDICAL UNIV
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