Modified fetus protection pill for intervening coronary artery stent postoperative cardiac rehabilitation

A technology of coronary artery and Baotai pills is applied in the application field of Jiawei Baotai pills in the field of cardiac rehabilitation after intervention of coronary stents, which can solve problems such as MIRI injury

Inactive Publication Date: 2020-07-31
杨丽华
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However, these therapeutic measures bring about another

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[0007] The acute myocardial infarction model was established by ligating the left anterior descending coronary artery. ①The AMI rat model was established by ligation of the left anterior descending artery, and the left ventricular end-diastolic diameter (LVIDd) and left ventricular systolic End internal diameters (LVIDs), left ventricular diastolic posterior wall thickness (LVPWsd), left ventricular systolic posterior wall thickness (LVPWs), left ventricular ejection fraction (LVEF) and left ventricular short-axis ratio (LVFS), to judge systolic function And ejection function, changes in the structural state of the ventricular wall, confirmed the protective effect of Jiawei Baotai Pill on the cardiac response of AMI rats. ②HE staining was used to observe the pathomorphological changes of myocardial tissue in AMI rats, and confirmed the protective effect of Jiawei Baotai Pill on the pathological morphology of myocardial tissue in AMI rats. ③ Electrochemiluminescence method was ...

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Abstract

The invention relates to a modified fetus protection pill for intervening coronary artery stent postoperative cardiac rehabilitation. According to the modified fetus protection pill for intervening coronary artery stent postoperative cardiac rehabilitation, the pathological change degree of myocardial tissue of rats can be significantly reduced, inflammatory factors can be significantly inhibited,the apoptosis quantity of myocardial cells can be significantly decreased, the expression level of Sirt3 protein in the myocardial tissue of the rats can be significantly increased, and the AMPK andmTOR levels can be significantly reduced. It is indicated that the modified fetus protection pill can significantly relieve myocardial tissue injuries of the myocardial ischemia-reperfusion injury model rats and inhibit myocardial cell apoptosis, and the effect can be achieved by up-regulating Sirt3 in mitochondria so as to inhibit expression of an AMPK/mTOR pathway.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to the application of Jiawei Baotai Pill in heart rehabilitation after coronary artery stent intervention. Background technique [0002] Acute myocardial infarction (AMI) has become one of the diseases that threaten human health. It has the characteristics of high morbidity, high mortality, and high recurrence rate. It is listed as the three major diseases that threaten human health together with cerebrovascular disease and cancer. When AMI is injured, it will cause myocardial cell swelling, decreased oxygen and sugar utilization rate, a large amount of calcium salt deposition in the cell, mitochondrial structural dysfunction, weakened myocardial cell contraction function and decreased ventricular compliance. This reaction is called ischemia-reperfusion. injury (MIRI). Due to the recovery of blood perfusion after transient myocardial ischemia, the ischemia and ti...

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Application Information

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IPC IPC(8): A61K36/8966A61K9/20A61P9/10A61K35/36
CPCA61K9/20A61K35/36A61K36/232A61K36/236A61K36/282A61K36/344A61K36/346A61K36/46A61K36/481A61K36/538A61K36/575A61K36/746A61K36/8966A61P9/10A61K2300/00
Inventor 杨丽华李淑玲马春
Owner 杨丽华
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