AGE production inhibitor

A technology of inhibitors and apoptosis inhibitors, applied in skin care preparations, medical preparations containing active ingredients, dairy products, etc., can solve the problem of loss of molecular skin elasticity, achieve the purpose of inhibiting the generation of AGEs and avoiding side effects Effect

Active Publication Date: 2013-01-16
ORIZA YUKA KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The formation of cross-linked structures leads to stiffening o

Method used

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Examples

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Example Embodiment

[0129] As a preferred preparation method for obtaining the polyphenols of the above chemical formulas (1) to (7), a preparation method including the following steps (a) to (c) can be adopted:

[0130] (A) The step of extracting the flowers and / or leaves of cherry blossoms with 20-50wt% aqueous ethanol,

[0131] (B) After adsorbing the extract obtained in the step (a) on the adsorbent, eluting with water and removing the water-eluted components,

[0132] (C) After the step (b), the extract is eluted with a water-soluble solvent, and then the eluate is concentrated.

[0133] According to this kind of preparation method, an extract containing the polyphenols of the above chemical formulas (1) to (7) at a high concentration can be effectively obtained from the flowers and leaves of cherry blossoms.

[0134] The adsorbent in the step (b) can be used alone or in combination with known adsorbents such as ion exchange resins, synthetic adsorbent resins, activated carbon, chelating resins, silic...

Example Embodiment

[0184] Example

[0185] Hereinafter, embodiments of the present invention will be described. In addition, the examples shown below are for confirming the AGE inhibitory effect of the composition obtained according to the present invention, and the scope of the present invention is not limited by these products and production methods.

[0186] [1] Preparation of cherry extract (leaf, flower)

[0187] Sakura [Mountain cherry (Guanshan), Prunus lannesiana Wils.cv.Sekiyama] was extracted with 30% (W / W) aqueous ethanol for 1 hour (60°C). Subsequently, it was filtered and concentrated to obtain a cherry blossom extract (hereinafter also referred to as "cherry blossom extract essential oil / essence") (yield 5 wt%). The same treatment was performed to obtain a cherry leaf extract (hereinafter, also referred to as "cherry leaf extract essential oil / essence") (yield 4wt%). These sakura extract essential oils / essences and sakura leaf extract essential oils / essences were taken as Example 1 and...

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Abstract

Disclosed is an AGE production inhibitor or the like, which effectively inhibits the production of an advanced glycation end product (AGE), while having improved biological safety. Specifically disclosed is an AGE production inhibitor or the like, which contains an extract of cherry (preferably blossoms or leaves thereof) and/or a processed product of the extract as an active ingredient. The AGE production inhibitor or the like contains, as an active ingredient, at least one compound that is selected from the group consisting of 1-O-(E)-caffeoyl-ss-D-glucopyranoside, 1-O-(E)-coumaroyl-ss-D-glucopyranoside, 1-O-(E)-cinnamoyl-ss-D-glucopyranoside, kaempferol 3-O-ss-D-glucopyranoside, quercetin 3-O-ss-D-glucopyranoside, kaempferol 3-O-(6"-malonyl)-ss-D-glucopyranoside, and quercetin 3-O-(6"-malonyl)-ss-D-glucopyranoside.

Description

Technical field [0001] The present invention relates to a novel AGE production inhibitor. The AGE production inhibitor of the present invention also has an inhibitory effect on the apoptosis of fibroblasts caused by CML collagen (Carboxymethyl lysine-collagen) belonging to AGE, and is used as food and medicine , Cosmetics and other materials and widely used. Background technique [0002] Although there are still many ambiguities in the production process of AGE (Advanced Glycation End-products, hereinafter referred to as "AGE" in this specification), it is generally considered that the non-enzymatic glycosylation reaction is Its main body. That is, in the initial reaction, the amino group in the protein and the aldehyde group of the reducing sugar such as glucose produce a non-enzymatic reaction (Glycation), and the Amadori rearrangement product is formed by the Schiff base. In the later reaction, the above The rearrangement products form AGEs after a long period of complicate...

Claims

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Application Information

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IPC IPC(8): A61K36/73A23L1/30A61K8/60A61K8/97A61K31/7024A61K31/7048A61K36/00A61P3/10A61P9/10A61P13/12A61P25/00A61P27/02A61P43/00A61Q19/00C07H13/04C07H17/07
CPCA61K2236/30A61K31/7048A23C9/13A61K31/7024C07H13/04A61K8/602A23C2240/15A23L1/3002A61K8/97C07H17/07A61K36/736A61Q19/08A61K36/73A23G3/36A23G4/06A23L33/105A61K31/7028A61K31/7032A61K8/9789A61P13/12A61P17/00A61P25/00A61P27/02A61P43/00A61P9/00A61P9/10A61P3/10
Inventor 下田博司渡邉贵村井弘道吉川雅之
Owner ORIZA YUKA KK
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