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One or more hmos for reducing or preventing fatigue and/or improving focus or concentration

An attention, concentration technique used in one or more of the HMO domains used to reduce or prevent fatigue and/or improve concentration or concentration, capable of addressing problems such as treatment without symptoms of fatigue

Pending Publication Date: 2020-08-11
GLYCOM AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In all of these diseases and conditions, there is no adequate treatment for the fatigue symptoms of the condition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] A total of 163 male and female participants were recruited into the study. Participants completed a baseline screening survey in which they indicated any medical conditions, fatigue status, and various gastrointestinal and quality of life symptoms. For symptoms, a 5-point Likert scale was used, with 1 indicating "no symptoms" and 5 indicating "severe symptoms". Of the 163 participants, 84 showed elevated fatigue scores. In addition, the following basic conditions are indicated:

[0070] symptoms number of participants irritable bowel syndrome 36 diarrhea 42 constipate 24 allergy 46 food intolerance 36 depression 42 bowel disease 12 celiac disease 4

[0071] Each participant was provided with a sufficient amount of HMO for 3 weeks, with a daily dose of approximately 4 g of HMO. HMOs are supplied as 2'-FL alone, or as a 4:1 (by weight) mixture of 2'-FL and LNnT.

[0072] After 3 weeks of ingestion, each p...

Embodiment 2

[0076] From 48 hours postpartum to 33 days of age, 24 male piglets (each treatment group 12 only). From days 2-6 and days 7-33, piglets were fed at a rate of 285 ml and 325 ml reconstituted feed / kg body weight, respectively. Piglets were euthanized on day 32 or 33, and hippocampal tissue was collected for mRNA expression analysis.

[0077] About 20 mg of hippocampal tissue was introduced into a Lysing Matrix D tube (MP Biomedicals, Santa Ana, California, USA), placed on ice, and 650 μL of lysis buffer (Agencourt RNAdvance Tissue Kit , Beckman Coulter Company, Indianapolis, Indiana, USA (Beckman Coulter, Indianapolis, Indiana, USA)). exist (MP Biomedical, Santa Ana, CA, USA) agitated the tube 2 x 1 min at speed 6, then extracted 400 μl using the Agencourt RNAdvanceTissue Kit (Beckman Coulter, Indianapolis, IN, USA) following the manufacturer's recommendations. lysate. Using Quant-iT TM RiboGreen TM RNA Assay Kit (Invitrogen, Carlsbad, California, USA) on Spectramax M2...

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PUM

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Abstract

The invention relates to a human milk oligosaccharide (HMO) for use in reducing or preventing fatigue and / or improving focus or concentration on a mental or physical activity in a human. The inventionalso relates to a synthetic composition for use, comprising one or more of said HMOs. The invention further relates to a method for reducing or preventing fatigue and / or improving focus or concentration on a mental or physical activity by administering at least one HMO and the use of said one or more HMOs in a dietary management of a human.

Description

[0001] field of invention [0002] The present invention relates to methods, compounds and compositions for reducing fatigue and / or improving focus or focus on mental or physical activity in a human. Background technique [0003] Fatigue is the subjective feeling of tiredness that can have many possible causes and accompany many different conditions. Fatigue is considered a symptom because it is a subjective feeling reported by patients rather than an objective feeling that can be observed by others. Fatigue is distinct from sleepiness and is generally considered to be more chronic than sleepiness. [0004] Typically, fatigue is defined as physical or mental fatigue. Physical fatigue is the temporary inability of muscles to function optimally. The onset of muscle fatigue during physical activity is gradual and depends on the individual's level of physical fitness as well as other factors such as sleep deprivation and overall health. It can usually be reversed by rest. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A23L33/00A61P25/28
CPCA61K31/702A61P25/28A23V2002/00A23L33/125A23V2200/31A23V2200/322A23V2250/28
Inventor B·麦康奈尔L·K·比格斯奈斯I·D·阿蒙森
Owner GLYCOM AS
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