Anti-tumor composition and preparation method thereof

A composition and anti-tumor technology, applied in the field of biomedicine, can solve the problems of limited anti-tumor activity, poor patient tolerance, and large toxic and side effects, and achieve the effect of simple and easy preparation method, low price, and small toxic and side effects

Inactive Publication Date: 2020-08-18
CHENGDU ZHIA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment methods for tumors mainly include surgery, radiotherapy, chemotherapy, and biological therapy. Among them, chemotherapy is still the main treatment method, but it is well known that the existing chemotherapy drugs have limited anti-tumor activity and relatively large toxic and side effects. Poorly tolerated by patients and expensive
Chinese medicine is a powerful weapon used by Chinese medicine to prevent and treat diseases. Chinese medicine treats malignant tumors, whether it is in reducing clinical symptoms, improving the quality of life, preventing recurrence and metastasis, prolonging the survival period, or cooperating with radiotherapy and chemotherapy, synergizing and reducing toxicity. Has a good effect, however, its effect is slow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] An anti-tumor composition, characterized in that it includes the following components in parts by weight: 20 parts of indole-2,6-dicarboxylic acid / 2,5-furandimethanol polycondensate, selenomethionine modified overspend 10 parts of ethylene glycol chitosan.

[0024] The preparation method of the indole-2,6-dicarboxylic acid / 2,5-furandimethanol polycondensate comprises the following steps: indole-2,6-dicarboxylic acid, 2,5-furandimethanol, Cobalt acetate is added to the polymerization reactor, and the esterification reaction is carried out at a pressure of 0.3MPa and a temperature of 250°C. The esterification reaction is completed when the theoretical water output reaches more than 98%, and then polycondensation is carried out at a vacuum degree of 150Pa and a temperature of 260°C. React for 6 hours, then continue to carry out polycondensation reaction under the condition of vacuum degree of 20Pa and temperature of 270°C for 6 hours, after discharging, cooling, washing, p...

Embodiment 2

[0028] An anti-tumor composition, characterized in that it comprises the following components in parts by weight: 23 parts of indole-2,6-dicarboxylic acid / 2,5-furandimethanol condensation polymer, selenomethionine modified overspend 11 parts of ethylene glycol chitosan.

[0029] The preparation method of the indole-2,6-dicarboxylic acid / 2,5-furandimethanol polycondensate comprises the following steps: indole-2,6-dicarboxylic acid, 2,5-furandimethanol, Antimony acetate is added to the polymerization reactor, and the esterification reaction is carried out at a pressure of 0.35MPa and a temperature of 253°C. The esterification reaction is completed when the theoretical water output reaches more than 98%, and then polycondensation is carried out at a vacuum degree of 180Pa and a temperature of 263°C. React for 6.5 hours, then continue to carry out polycondensation reaction under the conditions of vacuum degree 30Pa and temperature 272°C for 7 hours, and then go through discharging...

Embodiment 3

[0033] An anti-tumor composition, characterized in that it includes the following components in parts by weight: 25 parts of indole-2,6-dicarboxylic acid / 2,5-furandimethanol polycondensate, selenomethionine modified overspend 13 parts of ethylene glycol chitosan.

[0034] The preparation method of the indole-2,6-dicarboxylic acid / 2,5-furandimethanol polycondensate comprises the following steps: indole-2,6-dicarboxylic acid, 2,5-furandimethanol, Ethylene glycol antimony is added to the polymerization reactor, and the esterification reaction is carried out at a pressure of 0.4MPa and a temperature of 255°C. The esterification reaction is completed when the theoretical water output reaches more than 98%, and then under the conditions of a vacuum of 200Pa and a temperature of 265°C The polycondensation reaction was carried out for 7 hours, and then the polycondensation reaction was continued for 8 hours under the conditions of vacuum degree of 40Pa and temperature of 275°C, and th...

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PUM

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Abstract

The invention discloses an anti-tumor composition, which is characterized by being prepared from the following components in parts by weight: 20 to 30 parts of indole-2, 6-dicarboxylic acid / 2, 5-furandimethanol polycondensate and 10 to 15 parts of selenomethionine modified hyperbranched ethylene glycol chitosan. The invention also discloses a preparation method of the anti-tumor composition. The anti-tumor composition disclosed by the invention is low in price, good in anti-tumor effect, small in toxic and side effects and capable of remarkably improving the life quality, preventing recurrenceand metastasis and prolonging the life cycle.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an antitumor composition and a preparation method thereof. Background technique [0002] In recent years, with the development of medicine and the advancement of science and technology, various infectious diseases and common diseases have been gradually controlled by people. However, due to its strong concealment, long incubation period, and high mortality, malignant tumors have become the second largest killer of human beings in terms of mortality after cardiovascular diseases, seriously threatening our lives. How to suppress tumors correctly and effectively has become the focus of attention. [0003] At present, the treatment methods for tumors mainly include surgery, radiotherapy, chemotherapy, and biological therapy. Among them, chemotherapy is still the main treatment method, but it is well known that the existing chemotherapy drugs have limited anti-tumor activity and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/787A61K33/34A61K47/61A61K47/18A61P35/00A61P35/04
CPCA61K31/787A61K33/34A61K47/183A61K47/61A61P35/00A61P35/04A61K2300/00
Inventor 向兴力
Owner CHENGDU ZHIA TECH CO LTD
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