Application of polypeptide in preparing medicine for treating pancreatitis and medicine containing polypeptide
A technology for pancreatitis and acute pancreatitis, which is applied in the field of medicine to achieve the effects of low immunogenicity, small molecular weight of polypeptides and wide application prospects
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Embodiment 1
[0034] Embodiment 1, the synthesis of polypeptide
[0035] Polypeptide TDL23, ERG15 and cERG15 of the present invention are synthesized by solid-phase synthesis process, with a purity >95%, and the HPLC spectra of TDL23, ERG15 and cERG15 are respectively Figure 1A , Figure 1B and Figure 1C , Synthesize 500mg.
Embodiment 2
[0036] Example 2. Therapeutic effect of TDL23 polypeptide on acute pancreatitis in rats
[0037] Modeling: 96 male SD rats of SPF grade, weighing 230-260 g. The SD rats in each group were anesthetized, skin-prepared, and disinfected. A 2-3 cm transverse incision was made into the abdomen at 1-2 cm below the xiphoid process in the middle of the upper abdomen. Determine the liver, stomach, and spleen, find the duodenum by following the stomach, find the pancreas between the duodenal mesentery and the spleen at the back of the stomach, and find the opening of the transparent bile-pancreatic duct and the duodenum at the opening along the inner side of the duodenum. Intestinal big nipples. The common hepatic duct was ligated with an arterial clip near the hilum, and then the needle was advanced obliquely from the side of the duodenum and the direction of the needle was adjusted so that it could enter the bile-pancreatic duct. Slowly inject 2.5% sodium taurocholate 1 mL / kg retrograd...
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