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Cortex eucommiae extract for treating psoatic strain and preparation method of cortex eucommiae extract

An extraction method and extract technology, applied in the field of Eucommia ulmoides extract for treating lumbar muscle strain and its preparation, can solve problems such as easy recurrence and long treatment time, achieve good therapeutic effect, treat lumbar muscle strain, and solve the problem of insufficient utilization high effect

Inactive Publication Date: 2020-09-11
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pharmaceutical composition also uses the original drug as a drug component, the treatment time is long, and it is easy to relapse

Method used

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  • Cortex eucommiae extract for treating psoatic strain and preparation method of cortex eucommiae extract
  • Cortex eucommiae extract for treating psoatic strain and preparation method of cortex eucommiae extract
  • Cortex eucommiae extract for treating psoatic strain and preparation method of cortex eucommiae extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0041] Example 1-4 A kind of Eucommia extract for treating lumbar muscle strain

[0042] example Eucommia Chlorogenic Acid Eucommia flavonoids Eucommia polysaccharide Example 1 10 copies 15 copies 20 copies Example 2 18 copies 35 copies 45 copies Example 3 16 copies 30 copies 40 copies Example 4 20 copies 40 copies 50 copies

[0043] The preparation method of described extract comprises the following steps:

[0044] Extraction method of Eucommia chlorogenic acid

[0045] S1-1. Dried eucommia leaves, pulverized and added petroleum ether, ultrasonically extracted at 40°C and 100 Hz, repeated twice, and filtered to separate the filtrate and filter residue;

[0046] S1-2. Soak the filter residue in step S1-1 with 80% ethanol, reflux at 70°C for 2 hours, filter, and distill the filtrate under reduced pressure to obtain the crude extract of Eucommia ulmoides;

[0047]S1-3. Add 80% ethanol to dissolve the crude extract ...

Embodiment 5-8

[0056] Example 5-8 A kind of Eucommia extract for treating lumbar muscle strain

[0057] example Eucommia Chlorogenic Acid Eucommia flavonoids Eucommia polysaccharide Example 5 20 copies 30 copies 20 copies Example 6 10 copies 20 copies 50 copies Example 7 15 copies 35 copies 27 copies Example 8 18 copies 40 copies 45 copies

[0058] The preparation method of described extract comprises the following steps:

[0059] Extraction method of Eucommia chlorogenic acid

[0060] S1-1. Dried eucommia leaves, pulverized and added petroleum ether, ultrasonically extracted at 45°C and 120 Hz, repeated twice, and filtered to separate the filtrate and filter residue;

[0061] S1-2. Soak the filter residue in step S1-1 with 90% ethanol, reflux at 80°C for 2 hours, filter, and distill the filtrate under reduced pressure to obtain the crude extract of Eucommia ulmoides;

[0062] S1-3. Add 90% ethanol to dissolve the Eucommia crud...

Embodiment 1-8

[0103] Embodiment 1-8 group: start to take pharmaceutical composition A-H from the 2nd day after modeling, every day 3 times, every time 300mg / kg, at the same point of time on the 1st, 3rd, 5th, 7th day after treatment (8 am point) to obtain materials.

[0104] Comparative example 1-5 group: start to take pharmaceutical composition I-M from the 2nd day after modeling, every day 3 times, every time 300mg / kg, at the same time point (8 am in the morning) on ​​the 1st, 3rd, 5th, 7th days after treatment point) to obtain materials.

[0105] SPSS 20.0 software was used for statistical analysis, and statistical data were expressed as mean ± standard deviation.

[0106] Table 2 Comparison of MOD values ​​of Beclin1 expression in multifidus muscle in different time periods of rats in each group (optical density value, mean ± standard deviation)

[0107]

[0108]

[0109] Note: Compared with the blank group, a P≤0.01; compared with the model group, b P≤0.01

[0110]According ...

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Abstract

The invention provides a cortex eucommiae extract for treating psoatic strain and a preparation method of the cortex eucommiae extract, and belongs to the technical field of extraction of traditionalChinese medicines. The cortex eucommiae extract comprises the components in parts by weight of 10-20 parts of cortex eucommiae chlorogenic acid, 15-40 parts of cortex eucommiae flavone and 20-50 partsof cortex eucommiae polysaccharide.Extraction methods are controlled to respectively extract effective components of chlorogenic acid, flavone and polysaccharide in cortex eucommiae, effective components of medicines can be well released to the greater extent, the waste of traditional Chinese medicines is reduced, the ratio by weight of the chlorogenic acid to the polysaccharide is controlled tobe 1 to (1-5), and the obtained medical composition can effectively treat psoatic strain and is good in treatment effect.

Description

technical field [0001] The invention belongs to the technical field of extraction of traditional Chinese medicines, and in particular relates to an extract of Eucommia ulmoides for treating lumbar muscle strain and a preparation method thereof. Background technique [0002] With the continuous improvement of people's living standards, the time for mental work has increased greatly, and some civilized diseases such as lumbar muscle strain have come quietly, seriously affecting people's normal life, work and study. In daily life, long-term fixed positions or bad postures can easily cause lumbar muscle strain. Lumbar muscle strain is mainly caused by chronic accumulation of soft tissue in the waist. Mild cases cause muscle fiber degeneration, severe cases may gradually tear, edema, hemorrhage, and then fibrosis. When local palpation, it can be buckled and cord-like or nearly Round induration, if the lumbar muscle strain is not treated in time, it will recur, which will easily ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/46A61P21/00A61P19/10C07C67/48C07C69/732C08B37/00A23L33/105A61K127/00
CPCA61K36/46A61P21/00A61P19/10C07C67/48C08B37/0003A23L33/105C07C2601/14A61K2236/333A23V2002/00C07C69/732A23V2250/21A23V2200/316A23V2300/14
Inventor 李小锋刘厚权夏淑英张金良毛金娣周朝忠肖绍川
Owner JIANGXI POZIN PHARMA
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