Application of lncRNA AK024561 as a diagnostic marker for ovarian cancer
A technology of ovarian cancer and diagnostic kits, applied in the field of diagnostic markers, can solve problems such as difficult early diagnosis, and achieve the effects of high diagnostic accuracy, high specificity, and high sensitivity
Active Publication Date: 2022-04-26
SHANDONG UNIV QILU HOSPITAL
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Problems solved by technology
However, the current research on lncRNAs is mainly focused on ovarian cancer tissues or cells, and tissue sections are invasive detection, which is difficult to achieve early diagnosis. How to use non-invasive means to analyze lncRNAs has become a research hotspot in this field
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Embodiment 1
[0046] 1. Inclusion and exclusion criteria of experimental subjects:
[0047] (1) Source of cases
[0048] All cases were from inpatients in Qilu Hospital of Shandong University from January 2017 to December 2017. The blood samples of the normal control group were all from healthy persons who had undergone physical examination at Qilu Hospital of Shandong University. They had no heart, brain, lung, liver, kidney diseases and cancer diseases, and no known diseases affecting the research indicators.
[0049] (2) Diagnostic criteria
[0050] Diagnosis of ovarian cancer was based on histopathological examination, and staging was based on the 2013 edition of the International Federation of Gynecology and Obstetrics (FIGO) staging.
[0051] (3) Case exclusion criteria
[0052] (1) Tumors outside the ovary; (2) Those with incomplete pathology and medical records; (3) Those with coagulation disorders, infectious diseases, and infectious diseases; (4) Pregnant and lactating women. ...
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Abstract
The present invention specifically relates to the application of lncRNA AK024561 as a diagnostic marker for ovarian cancer. lncRNA plays an important physiological role in the occurrence and development of tumors. In order to further clarify the regulatory mechanism of lncRNA in ovarian cancer, the development of lncRNAs with diagnostic significance for ovarian cancer is expected to improve the probability of early diagnosis and survival of ovarian cancer patients. Specifically, the present invention proves through high-throughput deep sequencing expression verification that lncRNA AK024561 can be used as a biomarker for diagnosing ovarian cancer, and a corresponding detection kit has been developed, which has high detection sensitivity, high specificity, and convenient detection, meeting the The detection requirements for diagnosing ovarian cancer patients have been clinically verified to have a high diagnostic accuracy and have good practical application value.
Description
technical field [0001] The invention belongs to the technical field of diagnostic markers, and in particular relates to the application of long-chain non-coding RNA AK024561 as a diagnostic marker for ovarian cancer. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Ovarian cancer (OC) is one of the most common malignant tumors in women and the eighth most common cause of cancer death worldwide in recent years. With the rapid development of medical technology, people's understanding of ovarian cancer has made great progress, but the incidence and mortality of the disease are still high, and 125,000 people die from it every year worldwide. At present, the mortality rate of ...
Claims
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IPC IPC(8): C12Q1/6886G01N33/574
CPCC12Q1/6886G01N33/57449G01N33/57488C12Q2600/158C12Q2600/178C12Q2600/136G01N2500/04
Inventor 徐小飞董召刚徐银涛王玎
Owner SHANDONG UNIV QILU HOSPITAL