Degradable outer stent and preparation method and application of stent

A technology for external stents and degradable polymers, applied in the field of degradable external stents and its preparation, can solve the problems of single function and difficulty in improving the patency rate of vein grafts, achieve simple preparation methods, eliminate the risk of mechanical damage and infection, The effect of good flexibility and degradable performance

Pending Publication Date: 2020-10-13
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to their single function, it is difficult to achieve the results of improving the patency rate of vein grafts in clinical trials
So far, no external stent has achieved the goal of improving venous patency in clinical trials

Method used

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  • Degradable outer stent and preparation method and application of stent
  • Degradable outer stent and preparation method and application of stent
  • Degradable outer stent and preparation method and application of stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] This embodiment provides a degradable outer stent, including a chimeric material and a delivery substance, the chimeric material includes a degradable polymer substrate and a liquid metal material embedded in the degradable polymer substrate, and the delivery substance is set On the surface of liquid metal materials; such as figure 2 As shown, the embedded material includes a degradable polymer substrate 10 and a liquid metal material, and the liquid metal material includes a functional part 20 and a connecting part 30, from figure 2 It can be seen that the shape of the liquid metal material is a coplanar comb-shaped cross array pattern; the degradable polymer substrate is a PLCL substrate; the material of the liquid metal material is gallium indium eutectic, and the delivery substance is a plasmid.

[0059] image 3 is the scanning electron microscope image of the liquid metal material, from image 3 It can be seen that the relationship between the liquid metal and...

Embodiment 2

[0069] This embodiment provides a degradable outer stent, and the composition of the degradable stent is the same as that in Embodiment 1.

[0070] This embodiment provides a method for preparing a degradable outer stent, comprising the following steps:

[0071] (1) Intersect two comb electrodes on the same plane to form a patterned array, and prepare the patterned array into a screen printing mold in a ratio of 1:1;

[0072] (2) Add 3g gallium indium eutectic (Sigma Company, USA) and 1mL n-decyl alcohol (Macklin Company, China) into a centrifuge tube for ultrasonic treatment for 1min to obtain liquid metal ink; then use the screen printing prepared in step (1) The mold prints the liquid metal ink on the PET film, puts it in an oven at 80°C, and dries it to obtain a PET film layer with liquid metal ink;

[0073] (3) 20% mass fraction PLCL (Evonik company, Germany) polymer solution dissolved in dichloromethane is poured on the dry PET film, and the film is surrounded by molds ...

Embodiment 3

[0077] This embodiment provides a degradable outer stent, and the composition of the degradable stent is the same as that in Embodiment 1.

[0078] This embodiment provides a method for preparing a degradable outer stent, comprising the following steps:

[0079] (1) Intersect two comb electrodes on the same plane to form a patterned array, and prepare the patterned array into a screen printing mold in a ratio of 1:1;

[0080] (2) Add 3g gallium indium eutectic (Sigma Company, USA) and 1.5mL n-decyl alcohol (Macklin Company, China) into a centrifuge tube for ultrasonic treatment for 4min to obtain liquid metal ink; then use the screen prepared in step (1) The printing mold prints the liquid metal ink on the PET film, puts it in an oven at 60°C, and dries it to obtain a PET film layer with liquid metal ink;

[0081](3) 5% mass fraction PLCL (Evonik company, Germany) macromolecule solution that will be dissolved in methylene chloride is poured on the dry PET film, and the periph...

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Abstract

The invention provides a degradable outer stent and a preparation method and application of the stent. The degradable outer stent comprises a chimeric material and a delivery substance, the chimeric material comprises a degradable polymer substrate and a liquid metal material embedded in the degradable polymer substrate, and the delivery material is arranged on the surface of the liquid metal material; the degradable outer stent is mainly used in coronary artery bypass grafting, peripheral artery bypass grafting or artificial arteriovenous fistula surgery, can be implanted in the peripheral ofa vein graft or the peripheral of other pathological dilated vessels, and plays a role of mechanical support; in addition, the liquid metal material with specific morphology and composition are selected in the degradable outer stent, and extensive electroporation of vascular wall can be realized, so as to deliver plasmids, drugs, proteins and other substances; and the integration of electroporation into the outer stent with purely mechanical support, so as to improve the effect of the outer stent on inhibiting intimal hyperplasia of vein.

Description

technical field [0001] The invention belongs to the field of stents, and relates to a degradable outer stent and a preparation method and application thereof. Background technique [0002] In coronary artery bypass grafting, peripheral artery bypass grafting, and artificial arteriovenous fistula surgery, native veins are grafted into the arterial environment as graft vessels. This change in the mechanical and physiological environment leads to remodeling of the vein wall, intimal hyperplasia, and narrowing of the lumen. This results in a low patency of the vein graft and affects the effectiveness of the surgery. Taking coronary artery bypass grafting as an example, the 10-year patency rate of the vein graft is only about 50%, while the 10-year patency rate of the left internal mammary artery is above 90%. An external stent is a support structure implanted to wrap around a vein graft and limit its expansion. In recent years, reports on preclinical research and clinical res...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/30A61N1/32A61M31/00A61F2/06A61L31/12A61L31/14A61L31/16
CPCA61F2/06A61L31/128A61L31/14A61L31/148A61L31/16A61L2300/416A61M31/002A61N1/306A61N1/327C08L67/04
Inventor 蒋兴宇丁力成诗宇张岩杭晨
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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